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The investigators will test the following hypotheses:
1. Bedrest will blunt the anabolic response to a mixed nutrient meal, facilitating a loss of muscle mass and functional capacity that is only partially restored during rehabilitation.
2. Enriching daily meals with leucine will promote protein synthesis and maintain the anabolic response to mixed nutrient meal ingestion. This will preserve lean muscle mass and function during bedrest and facilitate the recovery of functional and metabolic capacity during rehabilitation.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
The University of Texas Medical Branch
The University of Texas, Galveston
Published on BioPortfolio: 2014-08-27T03:19:42-0400
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A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE.
An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. Leucine dehydrogenase catalyzes the reversible oxidative deamination of L-LEUCINE, to 4-methyl-2-oxopentanoate (2-ketoisocaproate) and AMMONIA, with the corresponding reduction of the cofactor NAD+.
A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.
An enzyme that activates leucine with its specific transfer RNA. EC 184.108.40.206.
One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.
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