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Biology of Thymic Tumors

2014-07-23 21:13:33 | BioPortfolio

Summary

This is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.

Description

The aim of the present study is to investigated the genetic alterations in tumor samples of a series of all WHO-defined subtypes of thymoma patients using high resolution microarray- comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the data to identify specific patterns of genetic aberrations and genes associated with each subtype. Moreover, tumor samples will be also investigated for some specific potential therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ hybridization (FISH) analysis. All these biological data will be correlated with clinical patients characteristics and survival data.

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Conditions

Thymoma

Location

Istituto Clinico Humanitas
Rozzano
Milano
Italy
20089

Status

Completed

Source

Istituto Clinico Humanitas

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:13:33-0400

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PubMed Articles [29 Associated PubMed Articles listed on BioPortfolio]

Clinical characteristics, risk factors, and outcomes after adjuvant radiotherapy for patients with thymoma in the United States: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Registry (1988-2013).

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Sclerosing thymoma: A rare case report and brief review of literature.

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Progressive peripheral CD8 T lymphocytosis complicated by pure red cell aplasia following immunosuppressive therapy for thymoma-associated myasthenia gravis.

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Ectopic hamartomatous thymoma (biphenotypic branchioma): A case report and review of the literature.

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Medical and Biotech [MESH] Definitions

A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)

A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)

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