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The purposes of this study are:
- To determine if the absolute decrease measured in primary tumor fluoro-L-thymidine (FLT) uptake maximum standardized uptake value and kinase (SUV max and Ki) between pre-treatment imaging and imaging after the first cycle of therapy differs in patients categorized as responders or non-responders based on classic clinical tumor radiographic response status (RECIST) measured after the second cycle of therapy.
- To determine if the absolute decrease measured in primary tumor FDG uptake (SUV lean-max) between pre-treatment imaging and imaging after the first cycle of therapy differs in patients categorized as responders or non-responders based on classic clinical tumor radiographic response status (RECIST) measured after the second cycle of therapy.
- To assess the effects of the combination of docetaxel and cisplatin on fractional tumor viability and proliferative fraction pre and post treatment and to correlate these with the PET SUV data for both tracers.
- To assess the methylation status of the dihydrofolate reductase gene gene from pre-treatment tumor biopsies and correlate methylation status with clinical and pathologic response.
Allocation: Non-Randomized, Control: Historical Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Non Small Cell Lung Cancer
FLT PET, Neoadjuvant Docetaxel and Cisplatin
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Sidney Kimmel Comprehensive Cancer Center
Published on BioPortfolio: 2014-08-27T03:19:51-0400
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