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High-dose Antioxidants for Central Serous Chorioretinopathy

2014-08-27 03:19:51 | BioPortfolio

Summary

Central serous chorioretinopathy (CSC) is the serous neurosensory detachment that usually involves the macular area. It is common in patients between 30-50 years old and effects male more often than female with the ratio of 5-10. The common risk factors are psychologic stress, type A personality, systemic steroid use, hypertension and pregnancy. The treatment is usually observation especially in the first three-months. The laser or photodynamic therapy should be considered when the condition does not improve after that time. Nevertheless, the pathogenesis of CSC is still not well understood but the study from indocyanine green angiography showed the choroidal vascular hyperpermeability and abnormal leakage. The causes of this abnormality are supposed to be from nitric oxide, prostaglandins or even free oxidative radicals. From this hypothesis, the oxidative process might be involved in the pathogenesis of the disease especially in the early stage. This study is to determine the effect of antioxidants drugs in the acute stage of CSC and to determine whether they can improve the outcomes of the disease.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Central Serous Chorioretinopathy

Intervention

antioxidants tablets

Location

Department of Ophthalmology, Faculty of medicine, Prince of Songkla university
Hat Yai
Songkhla
Thailand
90110

Status

Completed

Source

Prince of Songkla University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:51-0400

Clinical Trials [1126 Associated Clinical Trials listed on BioPortfolio]

Intravitreal Ranibizumab Treatment of Central Serous Chorioretinopathy

The purpose of this study is to examine the effects of Lucentis for active Central Serous Chorioretinopathy.

Brinzolamide for the Treatment of Chronic Central Serous Chorioretinopathy

Examine the efficacy of brinzolamide for the treatment of central serous chorioretinopathy

Central Serous Chorioretinopathy Treated by Modified Photodynamic Therapy

The purpose of this study is to evaluate the effectiveness as well as the detrimental influence of half-dose and half-fluence modification of verteporfin photodynamic therapy (PDT) for the...

Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy

Central serous chorioretinopathy (CSC) has been known since it was first described by Von Graefe and termed “idiopathic detachment of the macula” in 1866, is a well-characterized disor...

Treatment Trial for Acute Central Serous Chorioretinopathy

Central serous chorioretinopathy (CSC) is a relatively frequent eye disease in younger patients. It is characterized by serous detachment of the neurosensory retina with or without serous ...

PubMed Articles [4849 Associated PubMed Articles listed on BioPortfolio]

PRESENTATION OF CENTRAL SEROUS CHORIORETINOPATHY IN TWO HUSBAND AND WIFE COUPLES.

Central serous chorioretinopathy (CSC) is a disease in which serous detachment of the neurosensory retina occurs over an area of leakage from the choriocapillaris through the retinal pigment epitheliu...

Predictors of Outcome During Eplerenone Therapy in Chronic Central Serous Chorioretinopathy:A Prospective, Open-Label Pilot Clinical Study.

To assess the treatment response and predictive factors following eplerenone treatment in chronic central serous chorioretinopathy (CSCR).

INSTRUMENTAL DIFFERENCE IN ASSESSING CHOROIDAL HYPERPERMEABILITY AND PHOTODYNAMIC THERAPY IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY.

To investigate the difference in choroidal hyperpermeability (CH) assessed using digital fundus camera (DFC) and scanning laser ophthalmoscope (SLO) and its effect on photodynamic therapy (PDT) outcom...

Clinical Features of Central Serous Chorioretinopathy with Type 1 Choroidal Neovascularization.

To evaluate the type 1 choroidal neovascularization (CNV) incidence and associated factors in eyes with central serous chorioretinopathy (CSC) DESIGN: Retrospective case series METHODS: Records of 363...

Correlation between morphological characteristics in spectral-domain-optical coherence tomography, different functional tests and a patient's subjective handicap in acute central serous chorioretinopathy.

The purpose of this study was to identify quantitatively measurable morphologic optical coherence tomography (OCT) characteristics in patients with an acute episode of central serous chorioretinopathy...

Medical and Biotech [MESH] Definitions

A visual impairment characterized by the accumulation of fluid under the retina through a defect in the retinal pigment epithelium.

Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)

Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).

One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)

A thin lining of closed cavities of the body, consisting of a single layer of squamous epithelial cells (MESOTHELIUM) resting on a thin layer of CONNECTIVE TISSUE, and covered with secreted clear fluid from blood and lymph vessels. Major serous membranes in the body include PERICARDIUM; PERITONEUM; and PLEURA.

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