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Allogeneic Mesenchymal Stem Cells Transplantation for Systemic Sclerosis (SSc)

2014-08-27 03:19:51 | BioPortfolio

Summary

This study will explore safety and efficacy of allogeneic mesenchymal stem cells transplantation (MSCT) to treat patients with diagnosis of systemic sclerosis(SSc) who have been resistant to multiple standard treatments. The underlying hypothesis is that the SSc condition is caused by an abnormal immune homeostasis that can be restored by MSCT.

Description

- To test a new approach using allogeneic derived mesenchymal stem cell based therapy (MSCT) to treat refractory SSc

- To determine the disease-free survival in SSc patients treated with MSCT

- To assess adverse events of allogeneic MSC transplantation

- To assess the association of remission for organ function, clinical score and SSc serology levels at baseline with disease-free survival

Study Design

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Systemic Sclerosis

Intervention

Allogeneic Mesenchymal Stem Cells (AlloMSC)

Location

the Affiliated Drum Tower Hospital of Nanjing University Medical School
Nanjing
Jiangsu
China
210008

Status

Recruiting

Source

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:51-0400

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