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Effects of ICA-105665 Using the Intradermal Capsaicin and Ultraviolet B (UV-B) Models in Healthy Male Subjects

2014-08-27 03:19:55 | BioPortfolio

Summary

The purpose of this study is:

- To determine the pharmacodynamic (PD) effects of ICA-105665 using the intradermal (ID) capsaicin model in healthy male subjects.

- To investigate the effect of ICA-105665 on inflammatory hyperalgesia using the ultraviolet B (UV-B) model in healthy male subjects.

Description

Subjects will receive either ICA-105665, ibuprofen or placebo in each treatment period. The order in which the treatments are administered will be randomized. A double dummy design will be used to maintain the blind. All subjects will return for a post-study visit 5 to 7 days after discharge from the unit in Treatment Period 3.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)

Conditions

Nociceptive Pain

Intervention

ICA-105665, ibuprofen, Placebo

Location

The Medicines Evaluation Unit
Manchester
United Kingdom
M23 9QZ

Status

Completed

Source

Icagen

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:55-0400

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