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The purpose of this study is:
- To determine the pharmacodynamic (PD) effects of ICA-105665 using the intradermal (ID) capsaicin model in healthy male subjects.
- To investigate the effect of ICA-105665 on inflammatory hyperalgesia using the ultraviolet B (UV-B) model in healthy male subjects.
Subjects will receive either ICA-105665, ibuprofen or placebo in each treatment period. The order in which the treatments are administered will be randomized. A double dummy design will be used to maintain the blind. All subjects will return for a post-study visit 5 to 7 days after discharge from the unit in Treatment Period 3.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
ICA-105665, ibuprofen, Placebo
The Medicines Evaluation Unit
Published on BioPortfolio: 2014-08-27T03:19:55-0400
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