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Metabolism of Lipids in Advanced Cancer

2014-08-27 03:19:55 | BioPortfolio

Summary

The causes of failing nutrition status in advanced cancer are not well known. The way fat is moved, stored, burned or changed into other compounds may be affected and will be followed in patients using a tracer and other blood tests. The investigators hypothesize that fat loss and wasting results from low essential fatty acid availability in the body. Changes may occur in the liver that limits distribution and availability of fat to the body as an energy source or for other essential functions.

Description

Weight loss in cancer is the result of breakdown of fat (lipid) and muscle protein reserves. This research will explore how people with cancer use fat in their body through the use of tracers and measures in the blood. A stable isotope of hydrogen called 'deuterium' is used to trace the production of different fats by the liver. Other methods will determine how much and what types of fat are transported around the body. Body composition will be determined by CT scan and related to fat measures.

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Conditions

Lung Neoplasms

Intervention

Blood draws, Oral administration of stable isotope (deuterium), Metabolic rate testing

Location

Alberta Cancer Board
Edmonton
Alberta
Canada
T6G 1Z2

Status

Not yet recruiting

Source

Alberta Health Services

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:55-0400

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Medical and Biotech [MESH] Definitions

Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.

Hydrogen. The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight 1. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.

Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.

Stable gold atoms that have the same atomic number as the element gold, but differ in atomic weight. Au-197 is a stable isotope.

Stable yttrium atoms that have the same atomic number as the element yttrium, but differ in atomic weight. Y-89 is the only naturally occurring stable isotope of yttrium.

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