Switch From Combivir to Truvada - Mitochondrial Effects

2014-08-27 03:19:57 | BioPortfolio


Study subjects receiving the antiretroviral (anti-HIV) Combivir will be randomized to switch to Truvada-containing HAART or continue on Combivir. Measurements before and after 6 months will include maximal oxygen consumption and exercise tolerance, lactate production and clearance, subcutaneous adipose tissue and limb fat contents, insulin resistance, liver and muscle fat contents, and plasma free fatty acid concentrations. The hypothesis underlying this study is that chronic therapy with thymidine analogue nucleoside reverse transcriptase inhibitors (NRTIs), including zidovudine (AZT), leads to clinically detectable mitochondrial dysfunction in several organ systems.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment




Truvada vs Combivir


St. Luke's-Roosevelt Hospital Center
New York
New York
United States




St. Luke's-Roosevelt Hospital Center

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:19:57-0400

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PubMed Articles [4 Associated PubMed Articles listed on BioPortfolio]

Correction: Immunological non-response and low hemoglobin levels are predictors of incident tuberculosis among HIV-infected individuals on Truvada-based therapy in Botswana.

[This corrects the article DOI: 10.1371/journal.pone.0192030.].

Hybrid stochastic framework predicts efficacy of prophylaxis against HIV: An example with different dolutegravir prophylaxis schemes.

To achieve the 90-90-90 goals set by UNAIDS, the number of new HIV infections needs to decrease to approximately 500,000 by 2020. One of the 'five pillars' to achieve this goal is pre-exposure prophyl...

"Free Testing and PrEP without Outing Myself to Parents:" Motivation to participate in oral and injectable PrEP clinical trials among adolescent men who have sex with men.

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HIV Antiretroviral Pre-Exposure Prophylaxis: Development Challenges and Pipeline Promise.

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Medical and Biotech [MESH] Definitions

None available.

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Relevant Topics

AIDS; Acquired Immune Deficiency Syndrome. HIV; Human Immunodeficiency Virus HIV infection causes AIDS. HIV infection also causes the production of anti-HIV antibodies, which forms the test for HIV in patients. People who have the HIV antibodies are ...

Human Immuno Deficiency Virus (HIV)
Human Immunodeficiency Virus (HIV), the causative agent of AIDS. The Human Immunodeficiency Virus, more commonly known as HIV, is a member of the lentivirus sub-set of the retrovirus family of pathogens. It causes AIDS, or Acquired Immuno Deficiency Sy...

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