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Switch From Combivir to Truvada - Mitochondrial Effects

2014-08-27 03:19:57 | BioPortfolio

Summary

Study subjects receiving the antiretroviral (anti-HIV) Combivir will be randomized to switch to Truvada-containing HAART or continue on Combivir. Measurements before and after 6 months will include maximal oxygen consumption and exercise tolerance, lactate production and clearance, subcutaneous adipose tissue and limb fat contents, insulin resistance, liver and muscle fat contents, and plasma free fatty acid concentrations. The hypothesis underlying this study is that chronic therapy with thymidine analogue nucleoside reverse transcriptase inhibitors (NRTIs), including zidovudine (AZT), leads to clinically detectable mitochondrial dysfunction in several organ systems.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

HIV

Intervention

Truvada vs Combivir

Location

St. Luke's-Roosevelt Hospital Center
New York
New York
United States
10025

Status

Completed

Source

St. Luke's-Roosevelt Hospital Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:57-0400

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PubMed Articles [5 Associated PubMed Articles listed on BioPortfolio]

Immunological non-response and low hemoglobin levels are predictors of incident tuberculosis among HIV-infected individuals on Truvada-based therapy in Botswana.

There is a high burden of tuberculosis (TB) in HIV antiretroviral programmes in Africa. However, few studies have looked at predictors of incident TB while on Truvada-based combination antiretroviral ...

HIV Prevention Drug's Slow Uptake Undercuts Its Early Promise.

Initially billed as a game changer, Truvada has faced multiple obstacles to widespread adoption.

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We present the case of an HIV-negative patient clinically diagnosed with relapsing-remitting MS who achieved significant disease improvement on Combivir (zidovudine/lamivudine). Within months of treat...

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This study aimed to identify health-promoting contents focused on HIV/Aids prevention in messages posted in a Facebook group for debates on the use of pre-exposure prophylaxis (PrEP). This was a prosp...

Validation of an LC-MS/MS assay to simultaneously monitor the intracellular active metabolites of tenofovir, emtricitabine, and lamivudine in dried blood spots.

The ability to monitor adherence to antiretroviral therapy is critical for the interpretation of outcomes from clinical studies of HIV, and for optimizing patient care. The antiretrovirals tenofovir (...

Medical and Biotech [MESH] Definitions

None available.

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