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Study of Bosutinib With Capecitabine in Solid Tumors and Locally Advanced or Metastatic Breast Cancer

2014-08-27 03:20:01 | BioPortfolio

Summary

This is a research study in 2 parts assessing the following parameters of the combination of the study drug called bosutinib and a drug called capecitabine: the safety, how well the subject body handles the study drug and preliminary anti-tumor activity as treatment for different types of cancers in part 1 and breast cancer only in part 2.

In part 1, subjects will receive bosutinib and capecitabine daily at different dose levels in order to determine the highest tolerated dose of the study drug. In part 2, subjects will receive bosutinib and capecitabine at this highest tolerated dose. In addition, genetic research testing (research analyses involving genes and gene products) will be performed on biological samples from subjects.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Advanced Breast Cancer

Intervention

Bosutinib, Capecitabine

Location

Boston
Massachusetts
United States
2114

Status

Recruiting

Source

Wyeth

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:20:01-0400

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