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This is a research study in 2 parts assessing the following parameters of the combination of the study drug called bosutinib and a drug called capecitabine: the safety, how well the subject body handles the study drug and preliminary anti-tumor activity as treatment for different types of cancers in part 1 and breast cancer only in part 2.
In part 1, subjects will receive bosutinib and capecitabine daily at different dose levels in order to determine the highest tolerated dose of the study drug. In part 2, subjects will receive bosutinib and capecitabine at this highest tolerated dose. In addition, genetic research testing (research analyses involving genes and gene products) will be performed on biological samples from subjects.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Advanced Breast Cancer
Published on BioPortfolio: 2014-08-27T03:20:01-0400
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