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This study is an evaluation of the benefit of adding artesunate to existing first and second line antimalarial therapies in Pakistan.
A placebo controlled trial was carried out to assess two potential benefits of Artesunate Combination Therapy (ACT): efficacy and potential for transmission reduction.
A randomised, double-blind placebo controlled study of the efficacy of chloroquine or sulphadoxine-pyrimethamine alone and in combination with primaquine or artesunate for the treatment of uncomplicated falciparum malaria.
3. CQ+ artesunate
Patients were allocated to treatment groups using a pseudo-randomised table split by age and sex.
- Clinical and parasitological cure/treatment failure by day 28.
- time to resolution of fever
- time to clearance of trophozoites
- time to clearance of gametocytes
- gametocyte carriage on or after day 7 after treatment
All clinical assessments and slide readings were carried out by staff blind to treatment arm. Slides were double read.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
Uncomplicated Falciparum Malaria
artesunate (AS), sulphadoxine-pyrimethamine (SP), Chloroquine (CQ), primaquine (PQ)
London School of Hygiene and Tropical Medicine
Published on BioPortfolio: 2014-08-27T03:20:02-0400
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