Study to Assess Neuroinflammation and Neurocognitive Function in Patients With Acute Hepatitis C and Chronic HIV Co-Infection - A Positron Emission Tomography (PET) Study

2014-08-27 03:20:02 | BioPortfolio


Subtle changes to the brain, which doctors find difficult to detect through conversation or examination, may occur in patients with HIV and/or hepatitis C infection. It is not currently known whether the brain is affected in early (or acute) hepatitis C.

This study plans to evaluate what happens to the brain in patients with HIV and early hepatitis C. The investigators will be comparing 3 groups of individuals:

- Group 1: Individuals with HIV infection and acute (early) hepatitis C infection

- Group 2: Individuals with HIV infection

- Group 3: Healthy volunteers

Individuals wishing to take part will complete a series of tests assessing different aspects of their brain including:

- 2 brain scans using different technology:

- Magnetic resonance imaging (MRI) brain scan with spectroscopy

- CT PET brain scan

- A computer game test which measures brain function

- 2 short questionnaires

Results of these tests will be analyzed and compared between 3 groups.

Study Design

Observational Model: Case Control, Time Perspective: Prospective


Acute Hepatitis C


St Mary's Hospital
United Kingdom
W2 1NY




Imperial College London

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:20:02-0400

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Medical and Biotech [MESH] Definitions

Acute INFLAMMATION of the LIVER in humans; caused by HEPATITIS E VIRUS, a non-enveloped single-stranded RNA virus. Similar to HEPATITIS A, its incubation period is 15-60 days and is enterically transmitted, usually by fecal-oral transmission.

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INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).

A family of hepatotropic DNA viruses which contains double-stranded DNA genomes and causes hepatitis in humans and animals. There are two genera: AVIHEPADNAVIRUS and ORTHOHEPADNAVIRUS. Hepadnaviruses include HEPATITIS B VIRUS, duck hepatitis B virus (HEPATITIS B VIRUS, DUCK), heron hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis B virus (HEPATITIS B VIRUS, WOODCHUCK).

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