A Phase 1 Study of ARRY-438162 in Patients With Advanced Solid Tumors Followed by an Expansion Cohort in Patients With Advanced or Metastatic Biliary Cancer

2014-08-27 03:20:02 | BioPortfolio


This is the first part of a 2-part study to assess the safety, tolerability, and pharmacokinetics of ARRY-438162 in patients with advanced solid tumors. This first part is an open-label dose escalation study to establish the maximum tolerated dose of ARRY-438162.

The second part, expansion at maximum tolerated dose (MTD), is designed to assess the safety, preliminary efficacy, pharmacokinetics (PK), pharmacodynamics (PD) in patients with advanced or metastatic biliary cancer. Approximately 30 patients from the US will be enrolled in Part 1 and approximately 25 patients from the US will be enrolled in Part 2.

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Advanced Solid Tumors




University of California, Los Angeles
Los Angeles
United States




Array BioPharma

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:20:02-0400

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