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Study of Specimens From Young Patients With Neuroblastoma

2014-08-27 03:20:03 | BioPortfolio

Summary

RATIONALE: Studying the genes expressed in specimens from patients with cancer may help doctors identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.

PURPOSE: This research study is looking at specimens from young patients with neuroblastoma.

Description

OBJECTIVES:

Primary

- Establish a robust mRNA gene expression classifier for improved outcome prediction in children with neuroblastoma by using real-time PCR to quantify mRNA levels from genes that have been shown in ≥ 2 independent studies to have predictive power.

- Identify microRNA (miRNA) patterns that have prognostic significance in NB as accumulating evidence indicates that alterations in miRNA expression play a critical role in tumorigenesis and can be used in prognostic evaluation.

- Perform an integrated analysis of the established microRNA classifier with our mRNA signature to determine whether it results in even better classification of NB tumors.

OUTLINE: Samples are analyzed for 59 prognostic genes by real-time quantitative PCR-based gene expression profiling.

PROJECTED ACCRUAL: A total of 150 samples from high-risk patients, 100 samples from medium-risk patients, and 100 samples from low-risk patients will be accrued for this study.

Study Design

N/A

Conditions

Neuroblastoma

Intervention

gene expression analysis, polymerase chain reaction, laboratory biomarker analysis

Status

Not yet recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:20:03-0400

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