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PREventative Study Against URate-Lowering Drug-Induced Gout Exacerbations (PRE-SURGE 2)

2014-08-27 03:20:03 | BioPortfolio

Summary

The purpose of this clinical research study is to determine the safety and effectiveness of an experimental drug called rilonacept in subjects with gout who are beginning allopurinol treatment for gout. Subjects will participate in this study for approximately 22 weeks. Rilonacept is being studied for use in preventing allopurinol-induced gout flares.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Gout

Intervention

placebo, rilonacept, rilonacept

Location

Berlin
Tainan
Germany

Status

Recruiting

Source

Regeneron Pharmaceuticals

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:20:03-0400

Clinical Trials [102 Associated Clinical Trials listed on BioPortfolio]

Study Utilizing Rilonacept in Gout Exacerbations

This purpose of this clinical research is to determine the efficacy and safety of an experimental drug called rilonacept in subjects with an acute gout attack. Subjects will participate in...

PREventative Study Against URate-lowering Drug-induced Gout Exacerbations 1

The purpose of this clinical research study is to determine the safety and effectiveness of an experimental drug called rilonacept in subjects with gout who are beginning allopurinol treat...

Study of the Safety and Effectiveness of Rilonacept for the Prevention of Gout Flares

This is a clinical research study to determine the safety and effectiveness of an experimental drug called rilonacept in subjects with gout who are beginning another additional treatment. ...

Review of Safety Using Rilonacept in Preventing Gout Exacerbations (RE-SURGE)

The purpose of this clinical research study is to determine the safety and effectiveness of an experimental drug called rilonacept in subjects with gout who are on urate-lowering therapy. ...

Rilonacept in Diabetes Mellitus Type 1

The purpose of this study is to determine whether rilonacept, a cytokine trap directed against interleukin-1β (IL-1β), preserves insulin secretory function in children with newly diagnos...

PubMed Articles [971 Associated PubMed Articles listed on BioPortfolio]

Acute Gout in Emergency Admissions - Patient Characteristics and Adherence of Care Processes to Current Guidelines.

Gout or hyperuricemia are both well known and common diseases. The prevalence of gout is increasing worldwide. Thus, patients with gout are becoming more common. Although there are several published g...

4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol is a potential agent for gout therapy as a dual inhibitor of XOD and NLRP3.

Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Both anti-hyperuricemia and ant...

Colorectal Cancer Among Gout Patients Undergoing Colonoscopy.

The connection between gout and various cancers remains unclear. We assessed the relationship between gout and colorectal cancer in a population of veterans.

Febuxostat for the treatment of hyperuricaemia in gout.

Febuxostat is a potent non-purine selective xanthine oxidase inhibitor approved by the FDA in 2009 for management of hyperuricemia in people with gout. Areas covered: The authors summarize the pre-cli...

Any sleep is a dream far away: a nominal group study assessing how gout affects sleep.

There are no qualitative studies of sleep in gout; the aim of this study was to examine the impact of gout on sleep.

Medical and Biotech [MESH] Definitions

Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.

An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.

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