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RATIONALE: Diagnostic procedures, such as positron emission tomography and computed tomography, may help learn the extent of disease and allow doctors to plan 3-dimensional conformal radiation therapy.
PURPOSE: This phase II trial is studying the side effects of positron emission tomography and computed tomography and to see how well it works in planning treatment for patients undergoing 3-dimensional conformal radiation therapy for non-small cell lung cancer that cannot be removed by surgery.
- Prospectively evaluate the technical feasibility of integrating PET-CT scan fusion in St. Luke's Hospital in patients with unresectable, stage I-IIIB non-small cell lung cancer who underwent radical 3-D conformal radiotherapy (3-DCRT). (Pilot)
- Determine the rate of PET-CT scan based treatment delivery. (Pilot)
- Determine the safety of PET-CT scan-based radiotherapy with regard to loco-regional disease control. (Phase II)
- Compare the gross tumor volume, planning target volume, and organs at risk dose volume histogram between a conventional 3-D conformal radiotherapy (3-DCRT) plan and a PET-CT-based 3-DCRT plan.
OUTLINE: Patients undergo a non-contrast computed tomography (CT) scan followed by a fludeoxyglucose F 18 positron emission tomography/computed tomography (PET/CT) imaging scan to plan treatment volumes. Patients undergo radical 3-dimensional conformal radiotherapy using the PET-CT gross treatment volume wherever possible.
After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months thereafter.
Primary Purpose: Diagnostic
computed tomography, 3-dimensional conformal radiation therapy, fludeoxyglucose F 18, radiation therapy treatment planning/simulation
Saint Luke's Hospital
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:20:03-0400
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This randomized phase II trial studies how well positron emission tomography (PET)/computed tomography (CT)-guided radiation therapy works compared to standard radiation therapy in treatin...
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Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.
Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.
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Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.
Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging.
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