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Positron Emission Tomography and Computed Tomography in Planning Treatment for Patients Undergoing 3-Dimensional Conformal Radiation Therapy for Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

2014-08-27 03:20:03 | BioPortfolio

Summary

RATIONALE: Diagnostic procedures, such as positron emission tomography and computed tomography, may help learn the extent of disease and allow doctors to plan 3-dimensional conformal radiation therapy.

PURPOSE: This phase II trial is studying the side effects of positron emission tomography and computed tomography and to see how well it works in planning treatment for patients undergoing 3-dimensional conformal radiation therapy for non-small cell lung cancer that cannot be removed by surgery.

Description

OBJECTIVES:

Primary

- Prospectively evaluate the technical feasibility of integrating PET-CT scan fusion in St. Luke's Hospital in patients with unresectable, stage I-IIIB non-small cell lung cancer who underwent radical 3-D conformal radiotherapy (3-DCRT). (Pilot)

- Determine the rate of PET-CT scan based treatment delivery. (Pilot)

- Determine the safety of PET-CT scan-based radiotherapy with regard to loco-regional disease control. (Phase II)

Secondary

- Compare the gross tumor volume, planning target volume, and organs at risk dose volume histogram between a conventional 3-D conformal radiotherapy (3-DCRT) plan and a PET-CT-based 3-DCRT plan.

OUTLINE: Patients undergo a non-contrast computed tomography (CT) scan followed by a fludeoxyglucose F 18 positron emission tomography/computed tomography (PET/CT) imaging scan to plan treatment volumes. Patients undergo radical 3-dimensional conformal radiotherapy using the PET-CT gross treatment volume wherever possible.

After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months thereafter.

Study Design

Primary Purpose: Diagnostic

Conditions

Lung Cancer

Intervention

computed tomography, 3-dimensional conformal radiation therapy, fludeoxyglucose F 18, radiation therapy treatment planning/simulation

Location

Saint Luke's Hospital
Dublin
Ireland
6

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:20:03-0400

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Medical and Biotech [MESH] Definitions

Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.

Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.

An imaging technique using a device which combines TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON and TOMOGRAPHY, X-RAY COMPUTED in the same session.

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.

Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging.

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