Positron Emission Tomography and Computed Tomography in Planning Treatment for Patients Undergoing 3-Dimensional Conformal Radiation Therapy for Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

2014-08-27 03:20:03 | BioPortfolio


RATIONALE: Diagnostic procedures, such as positron emission tomography and computed tomography, may help learn the extent of disease and allow doctors to plan 3-dimensional conformal radiation therapy.

PURPOSE: This phase II trial is studying the side effects of positron emission tomography and computed tomography and to see how well it works in planning treatment for patients undergoing 3-dimensional conformal radiation therapy for non-small cell lung cancer that cannot be removed by surgery.




- Prospectively evaluate the technical feasibility of integrating PET-CT scan fusion in St. Luke's Hospital in patients with unresectable, stage I-IIIB non-small cell lung cancer who underwent radical 3-D conformal radiotherapy (3-DCRT). (Pilot)

- Determine the rate of PET-CT scan based treatment delivery. (Pilot)

- Determine the safety of PET-CT scan-based radiotherapy with regard to loco-regional disease control. (Phase II)


- Compare the gross tumor volume, planning target volume, and organs at risk dose volume histogram between a conventional 3-D conformal radiotherapy (3-DCRT) plan and a PET-CT-based 3-DCRT plan.

OUTLINE: Patients undergo a non-contrast computed tomography (CT) scan followed by a fludeoxyglucose F 18 positron emission tomography/computed tomography (PET/CT) imaging scan to plan treatment volumes. Patients undergo radical 3-dimensional conformal radiotherapy using the PET-CT gross treatment volume wherever possible.

After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months thereafter.

Study Design

Primary Purpose: Diagnostic


Lung Cancer


computed tomography, 3-dimensional conformal radiation therapy, fludeoxyglucose F 18, radiation therapy treatment planning/simulation


Saint Luke's Hospital




National Cancer Institute (NCI)

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:20:03-0400

Clinical Trials [4271 Associated Clinical Trials listed on BioPortfolio]

PET Scans in Patients With Head And Neck Cancer Who Are Undergoing 3-Dimensional Conformal Radiation Therapy And Intensity-Modulated Radiation Therapy

RATIONALE: Imaging procedures, such as PET scans, may determine the extent of cancer and help doctors plan radiation therapy. Radiation therapy uses high-energy x-rays to kill tumor cells....

3-Dimensional Conformal Radiation Therapy or Internal Radiation Therapy After Breast-Conserving Surgery in Treating Women With Stage I or Stage II Breast Cancer

RATIONALE: Specialized radiation therapy, such as 3-dimensional conformal radiation therapy, that delivers a high dose of radiation directly to the tumor may kill more tumor cells and caus...

Study of Positron Emission Tomography and Computed Tomography in Guiding Radiation Therapy in Patients With Stage III Non-small Cell Lung Cancer

This randomized phase II trial studies how well positron emission tomography (PET)/computed tomography (CT)-guided radiation therapy works compared to standard radiation therapy in treatin...

Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who Have Undergone Surgery for Parotid Tumors

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cel...

Conformal Radiation Therapy in Treating Patients With Metastatic Cancer Outside the Brain

RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase...

PubMed Articles [15764 Associated PubMed Articles listed on BioPortfolio]

F-EF5 PET-based Imageable Hypoxia Predicts Local Recurrence in Tumors Treated With Highly Conformal Radiation Therapy.

Tumor hypoxia contributes to radiation resistance. A noninvasive assessment of tumor hypoxia would be valuable for prognostication and possibly selection for hypoxia-targeted therapies. F-pentafluorin...

Conformal Radiation Therapy for Pediatric Patients with Low-Grade Glioma: Results from the Children's Oncology Group Phase II Study XXXX.

To determine the rate of marginal relapse, progression-free survival (PFS), and overall survival (OS) in patients with pediatric low-grade glioma (PLGG) treated with conformal radiation therapy (CRT) ...

Chest Computed Tomography at Radiation Dose of a Posteroanterior and Lateral Chest X-ray Series: a Proof of Principle in Lymphangioleiomyomatosis.

Given the rising utilization of medical imaging and the risks of radiation, there is increased interest in reducing radiation exposure. The objective of this study was to evaluate, as a proof of princ...

Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands.

Computed tomography (CT), a strong diagnostic tool, delivers higher radiation doses than most imaging modalities. As CT use has increased rapidly, radiation protection is important, particularly among...

Association of Fludeoxyglucose F 18-Labeled Positron Emission Tomography and Computed Tomography With the Detection of Oropharyngeal Cancer Recurrence.

No guidelines at present describe when fludeoxyglucose F 18-labeled positron emission tomography and computed tomography (FDG PET-CT) should be used in the initial posttreatment period for evaluation ...

Medical and Biotech [MESH] Definitions

Computed tomography modalities which use a cone or pyramid-shaped beam of radiation.

Computed tomography where there is continuous X-ray exposure to the patient while being transported in a spiral or helical pattern through the beam of irradiation. This provides improved three-dimensional contrast and spatial resolution compared to conventional computed tomography, where data is obtained and computed from individual sequential exposures.

An imaging technique using a device which combines TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON and TOMOGRAPHY, X-RAY COMPUTED in the same session.

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.

Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging.

More From BioPortfolio on "Positron Emission Tomography and Computed Tomography in Planning Treatment for Patients Undergoing 3-Dimensional Conformal Radiation Therapy for Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery"

Quick Search


Relevant Topics

Clincial Trials
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...

Gilotrif (afatinib)
GILOTRIF (afatinib) is a kinase inhibitor indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L8...

Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...

Searches Linking to this Trial