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RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to chronic graft-versus-host disease in patients who have undergone donor stem cell transplant.
PURPOSE: This phase I trial is studying chronic graft-versus-host disease in patients who have undergone donor stem cell transplant.
- To determine and define the biological basis of different subtypes of chronic graft-vs-host disease using a targeted single nucleotide polymorphisms approach in patients who have undergone allogeneic stem cell transplantation.
OUTLINE: Samples are assessed for single nucleotide polymorphisms (SNPs) (e.g., TGF-β, mannose binding lectin, myeloperoxidase, HSP 70, minor histocompatability antigens, KIR, CCL5, NOD2/CARD15, TNFα, TNF R II, interleukin [IL]-10, IL-13, IL-6, IFN-γ, IL-1 RA, IL-23, and IL-15). Other candidate genes may be assessed and candidate SNPs will be added based on their relationship to acute graft-vs-host disease (GVHD), chronic GVHD, autoimmune disease, pharmacogenetics, and other immunologic processes. Genes are assessed for gene frequency.
polymorphism analysis, laboratory biomarker analysis
Vanderbilt-Ingram Cancer Center - Cool Springs
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:20:04-0400
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