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Effects of Ketamine on Human Bladders and Its Possible Mechanisms

2014-07-23 21:13:40 | BioPortfolio

Summary

This study is aimed to evaluate the relationship between ketamine abused and bladder dysfunction and its possible mechanisms.

Study Design

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Conditions

Cystitis

Intervention

ketamine

Location

Taipei Medical University-Wan Fang Hospital
Taipei
Taiwan

Status

Enrolling by invitation

Source

Taipei Medical University WanFang Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:13:40-0400

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PubMed Articles [193 Associated PubMed Articles listed on BioPortfolio]

Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis.

Ketamine is an ionotropic glutamatergic N‑methyl‑D‑aspartate receptor antagonist, which is widely used among recreational drug abusers. Ketamine abusers exhibit substantially reduced bladder cap...

Delayed Urinary Symptoms Induced by Ketamine.

One of the side-effects of ketamine abuse is genito-urinary damage. This report describes a case of a former ketamine user who presented with urinary symptoms associated with ketamine years after stop...

Ketamine in the treatment of acute pain.

Ketamine is an old anesthetic agent that relieves pain by reducing central sensitization in the central nervous system. This is advantageous for patients suffering from severe pain prior to surgery or...

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Case report : Emphysematous cystitis.

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Medical and Biotech [MESH] Definitions

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.

Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.

A condition with recurring discomfort or pain in the URINARY BLADDER and the surrounding pelvic region without an identifiable disease. Severity of pain in interstitial cystitis varies greatly and often is accompanied by increased urination frequency and urgency.

Frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladder inflammation (CYSTITIS).

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