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The purpose of the study is to determine if citicoline ( a naturally occurring chemical in your body) is effective in helping people reduce their dependence on methamphetamine. The investigators will use neuroimaging to look at the structure and chemical make up of the brain at the start of the study and after 8 weeks of treatment of citicoline or placebo.
This is a prospective, randomized, double-blind, placebo-controlled study, in which we will systematically evaluate the therapeutic effects of citicoline, which may both increase dopamine and normalize cognitive and structural deficits in the brain of methamphetamine dependent subjects. Newly assessed methamphetamine dependent subjects will undergo baseline and repeat cognitive assessments after 8 weeks of placebo or oral citicoline as a nutritional supplement. We will also evaluate the chemical and structural changes in brain regions identified by MRS, DTI and cortical thickness, which in turn are expected to recover after 8 weeks of citicoline treatment. Specific brain regions of interest include the prefrontal cortices, temporal cortex, and the caudate/putamen all of which are known to be involved in the pathophysiology of methamphetamine dependence.
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
University of Utah
Salt Lake City
University of Utah
Published on BioPortfolio: 2014-08-27T03:20:22-0400
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