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Validation of 70-gene MammaPrint Profile in Japanese Population

2014-08-27 03:22:02 | BioPortfolio

Summary

By using gene-expression profiling, Van't Veer and colleagues developed a 70-gene prognosis profile, MammaPrint, to identify breast cancer patients who are at low risk of developing distant metastases and therefore might safely be spared chemotherapy. The aim of this study is to evaluate the prognostic value of the 70-gene Mammaprint profile in Japanese women with node-negative breast cancer.

Description

Frozen tumor samples from 140 node-negative, breast cancer patients aged between 29 and 70 years at diagnosis are hybridized on MammaPrint array. Patients were treated with breast conserving therapy or mastectomy with axillary lymph node dissection between December 1998 and August 2001 at Osaka Medical Center for Cancer and Cardiovascular Diseases. Samples are evaluated by gene expression profiling for the 70-gene MammaPrint profile and classified as genomic high risk or genomic low risk.

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Conditions

Breast Cancer

Location

Osaka Medical Center for Cancer and Cadiovascular Diseases
Osaka
Japan

Status

Completed

Source

Agendia

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:22:02-0400

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