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Multidrug Resistance Proteins in Patients Enrolled in Clinical Trials Outside of the National Cancer Institute Center for Cancer Research

2014-08-27 03:22:19 | BioPortfolio

Summary

RATIONALE: Studying samples of tumor tissue or blood from patients with cancer in the laboratory may help doctors learn more about cancer and the development of multidrug resistance in patients.

PURPOSE: This laboratory study is looking at multidrug resistance proteins in patients enrolled in clinical trials outside of the National Cancer Institute Center for Cancer Research.

Description

OBJECTIVES:

- Determine expression of MDR-1 gene/P-glycoprotein and related drug resistance proteins in tumor tissue samples from patients enrolled in clinical trials outside of the National Cancer Institute Center for Cancer Research.

OUTLINE: Tumor tissue or blood samples that have been previously collected from patients are analyzed for P-glycoprotein and other multidrug transporters (e.g., MRP-1 and ABCG2) by immunohistochemistry, microarray analysis, and reverse transcriptase-polymerase chain reaction.

The identity of individual patients remains confidential. No results of sample analyses are provided to patients or family members.

PROJECTED ACCRUAL: An unlimited number of patient samples will be accrued for this study.

Study Design

N/A

Conditions

Brain and Central Nervous System Tumors

Intervention

gene expression analysis, protein expression analysis, reverse transcriptase-polymerase chain reaction, flow cytometry, immunohistochemistry staining method

Location

Arizona Clinical Research Center, Incorporated
Tucson
Arizona
United States
85715

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:22:19-0400

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