Advertisement

Topics

Immune Responses in Caucasian and Chinese Participants Exposed to the Epstein-Barr Virus

2014-08-27 03:22:20 | BioPortfolio

Summary

RATIONALE: Studying samples of blood from participants exposed to the Epstein-Barr virus in the laboratory may help doctors learn more about changes that occur in the immune system.

PURPOSE: This laboratory study is looking at immune responses in Caucasian and Chinese participants exposed to the Epstein-Barr virus.

Description

OBJECTIVES:

- Compare immune responses to the Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) in Caucasian vs Asian/Chinese participants.

- Determine a comprehensive T-cell epitope mapping of the EBV-encoded LMP-2 in these ethnically diverse populations.

OUTLINE: Participants undergo apheresis for the collection of autologous peripheral blood mononuclear cells (PBMC). PBMC are analyzed for HLA type by sequence-based typing and immune-dominant epitopes of Epstein-Barr virus (EBV)-associated latent membrane protein-2 (LMP-2) by epitope mapping.

PROJECTED ACCRUAL: A total of 60 participants (30 Caucasian and 30 Asian/Chinese) will be accrued for this study within 2 years.

Study Design

N/A

Conditions

Health Status Unknown

Intervention

gene mapping, microarray analysis, polymorphism analysis

Location

Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office
Bethesda
Maryland
United States
20892-1182

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:22:20-0400

Clinical Trials [3156 Associated Clinical Trials listed on BioPortfolio]

Biomarker Changes in Samples From Young Patients With Acute Myeloid Leukemia

RATIONALE: Studying samples of blood or tumor tissue from patients with cancer in the laboratory may help doctors learn about changes that occur in DNA and identify biomarkers related to c...

Study of Tissue Samples From Patients With Lymphoma

RATIONALE: Studying tissue samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. ...

Genetic Susceptibility or Resistance to Hepatitis B Virus in the Chinese Population

RATIONALE: Identifying genes that increase a person's susceptibility or resistance to hepatitis B virus infection may help the study of hepatitis. PURPOSE: This clinical trial is studying...

Genetic Study of Familial Factors in Patients With Colon Cancer

RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer. PURPOSE: Clinical trial to study the cancer-related genes i...

Study of Sperm Molecular Factors Implicated in Male Fertility

Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women ...

PubMed Articles [49699 Associated PubMed Articles listed on BioPortfolio]

Association Study of MMP-9 -1562C/T Gene Polymorphism with Susceptibility to Multiple Autoimmune Diseases: A Meta-analysis.

Matrix metalloproteinase-9 (MMP-9) -1562 C/T gene polymorphism has been identified as a susceptible gene for multiple autoimmune diseases (ADs), but studies are inconsistent. The aim of this study wa...

Myeloperoxidase polymorphism and coronary artery disease risk: A meta-analysis.

The myeloperoxidase (MPO) gene 463G/A and 129G/A polymorphisms have been reported to be associated with coronary artery disease (CAD), but the results remain inconclusive. This meta-analysis was desig...

Generalized Correlation Coefficient for Non-Parametric Analysis of Microarray Time-Course Data.

Modeling complex time-course patterns is a challenging issue in microarray study due to complex gene expression patterns in response to the time-course experiment. We introduce the generalized correla...

PRISMA-combined Myeloperoxidase -463G/A gene polymorphism and coronary artery disease: A meta-analysis of 4744 subjects.

Myeloperoxidase (MPO) -463G/A gene polymorphism may be associated with an increased risk of developing coronary artery disease (CAD). Studies on the subject, however, do not provide a clear consensus....

A single nucleotide polymorphism of AIRE gene located in the 21q22.3 increases the risk of rheumatoid arthritis.

Several studies addressed the association of autoimmune regulator (AIRE) gene polymorphism with the risk of rheumatoid arthritis (RA); however, their conclusions were inconsistent. For better investig...

Medical and Biotech [MESH] Definitions

The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format.

A multistage process that includes RNA cloning, physical mapping, subcloning, sequencing, and information analysis.

A multistage process that includes DNA cloning, physical mapping, subcloning, sequencing, and information analysis.

A center in the PUBLIC HEALTH SERVICE which is primarily concerned with the collection, analysis, and dissemination of health statistics on vital events and health activities to reflect the health status of people, health needs, and health resources.

Hybridization of a nucleic acid sample to a very large set of oligonucleotide probes, which are attached to a solid support, to determine sequence or to detect variations in a gene sequence or expression or for gene mapping.

More From BioPortfolio on "Immune Responses in Caucasian and Chinese Participants Exposed to the Epstein-Barr Virus"

Quick Search
Advertisement
 

Relevant Topics

Antibodies
An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be produc...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...


Searches Linking to this Trial