Efficacy Study of Vaginal Mifepristone to Treat Uterine Fibroids

2014-07-24 14:13:42 | BioPortfolio


The purpose of this study is to evaluate the effect of daily dosage of vaginally mifepristone on reduction of uterine fibroids size and the symptoms associated with uterine fibroids.


Uterine fibroids are benign tumors of the uterus made up of smooth muscle and the extracellular matrix proteins Collagen and Elastin. They are exceptionally common; the cumulative incidence of a diagnosis of fibroids in women aged 25 to 45 is approximately 30 percent.

Uterine fibroids can cause abnormal uterine bleeding, dysmenorrhea, lower back pain and non-cyclic pelvic pain. They also can contribute to symptoms related to an enlarging pelvic mass (e.g., urinary frequency or constipation).

Uterine fibroids are also associated with an increased risk of complications of pregnancy, and with infertility, although it is unclear whether this association is causative. Symptoms associated with uterine fibroids can have a significant impact on quality of life, with scores on standard measures that are comparable to those for other major chronic diseases

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Uterine Fibroid


mifepristone vaginal tablets


Gynecolaoy department - Shiba Medical Center Tel Hashomer
Ramat Gan




BioPro Medical Ltd

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T14:13:42-0400

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PubMed Articles [1044 Associated PubMed Articles listed on BioPortfolio]

The use of mifepristone in abortion associated with an increased risk of uterine leiomyomas.

To investigate the association between widespread use of mifepristone in abortions and risk of uterine leiomyomas.We conducted a case-control study of 305 patients with uterine leiomyomas between Janu...

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Medical and Biotech [MESH] Definitions

Downward displacement of the UTERUS. It is classified in various degrees: in the first degree the UTERINE CERVIX is within the vaginal orifice; in the second degree the cervix is outside the orifice; in the third degree the entire uterus is outside the orifice.

Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)

Bleeding from blood vessels in the UTERUS, sometimes manifested as vaginal bleeding.

UTERINE BLEEDING from a GESTATION of less than 20 weeks without any CERVICAL DILATATION. It is characterized by vaginal bleeding, lower back discomfort, or midline pelvic cramping and a risk factor for MISCARRIAGE.

The uptake of substances from the VAGINA via the vaginal epithelium/mucosa.

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