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Tanezumab in Osteoarthritis of the Hip or Knee (2)

2014-08-27 03:23:36 | BioPortfolio

Summary

Test the efficacy and safety of 2 doses of tanezumab compared with naproxen and placebo in patients with osteoarthritis

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Osteoarthritis

Intervention

tanezumab 10 mg, tanezumab 5 mg, naproxen, placebo

Location

Pfizer Investigational Site
Birmingham
Alabama
United States
35242

Status

Completed

Source

Pfizer

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:23:36-0400

Clinical Trials [967 Associated Clinical Trials listed on BioPortfolio]

Tanezumab In Osteoarthritis Of The Knee (2)

The purpose of this study is to test the efficacy and safety of 2 doses of tanezumab compared with naproxen and placebo in patients with osteoarthritis.

Long-Term Study Of The Safety Of Tanezumab In Arthritis Patients

Tanezumab, administered for up to 1 1/2 years, reduces the pain of osteoarthritis without affecting how nerve impulses are transmitted in sensory nerves

Efficacy And Safety Study Of Tanezumab Subcutaneous Administration In Osteoarthritis - A Subcutaneous/Intravenous Bridging Study

This is an efficacy and safety study of 3 doses (2.5 mg, 5 mg and 10mg) of tanezumab administered subcutaneously versus placebo. This study will also compare a subcutaneous (SC) administra...

Tanezumab in Osteoarthritis of the Hip or Knee

The purpose of the study is to test the efficacy and safety of 2 doses of tanezumab compared to oxycodone CR and placebo in patients with osteoarthritis

Tanezumab in Osteoarthritis of the Knee

Test the efficacy and safety of 3 doses in Osteoarthritis of the knee in patients.

PubMed Articles [1577 Associated PubMed Articles listed on BioPortfolio]

Staircase-evoked Pain may be More Sensitive than Traditional Pain Assessments in Discriminating Analgesic Effects: A Randomized, Placebo-controlled Trial of Naproxen in Patients with Osteoarthritis of the Knee.

Analgesic trials often fail to show a significant effect even when medications with known efficacy are tested. This could be attributed to insufficient assay sensitivity of analgesic trials, which may...

CGRP Blockade by Galcanezumab Was Not Associated with Reductions in Signs and Symptoms of Knee Osteoarthritis in a Randomized Clinical Trial.

This study tested whether galcanezumab, a humanized monoclonal antibody with efficacy against migraine, was superior to placebo for the treatment of mild or moderate osteoarthritis (OA) knee pain.

Efficacy and Safety of Single-Dose OnabotulinumtoxinA in the Treatment of Symptoms of Osteoarthritis of the Knee: Results of a Placebo-Controlled, Double-Blind Study.

To evaluate intraarticular onabotulinumtoxinA 400 U and 200 U in reducing symptoms of knee osteoarthritis (OA) in patients with nociceptive pain.

Sleep interventions for osteoarthritis and spinal pain: a systematic review and meta-analysis of randomized controlled trials.

To determine if sleep interventions improve pain and sleep in people with osteoarthritis and/or spinal pain compared to control/placebo.

Naproxen ecotoxicity and biodegradation by Bacillus thuringiensis B1(2015b) strain.

High level of naproxen consumption leads to the appearance of this drug in the environment but its possible effects on non-target organisms together with its biodegradation are not well studied. The a...

Medical and Biotech [MESH] Definitions

An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.

Viscoelastic solutions that are injected into JOINTS in order to alleviate symptoms of joint-related disorders such as OSTEOARTHRITIS.

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