Topics

Effects of H1-Antagonist on Cognition

2014-08-27 03:24:13 | BioPortfolio

Summary

The purpose of this study is to determine whether histamine is involved in memory and specific processes in human cognition.

Description

The neurotransmitter histamine appears to be involved in human cognitive performance. However, the exact role is very unclear. The role it plays in memory performance is highly disputed, as animal studies show decreased performance when the H1-receptor is blocked in the central nervous system while such findings in humans is scarce. To clarify the role of histamine in human memory and different processes in cognition, the effects of an H1-antagonist (dexchlorpheniramine) on memory, alertness and sensory and motor processes are measured. The study will be conducted according to a within subject cross-over design using healthy volunteers.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Conditions

Cognition

Intervention

dexchlorpheniramine, lorazepam

Location

Faculty of Psychology and Neuroscience, Maastricht University
Maastricht
Limburg
Netherlands
6229 ER

Status

Completed

Source

Maastricht University Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:24:13-0400

Clinical Trials [303 Associated Clinical Trials listed on BioPortfolio]

A Sedation/Cognition/Electroencephalogram (EEG) Study Using AZD7325 and Comparator.

The purpose of the study is to determine the effects of the compound AZD7325 as compared to lorazepam on sleepiness, concentration and brain activity.

Comparison Between Dexchlorpheniramine and Dexchlorpheniramine/Pseudoephedrine/Guaifenesin in Respiratory Infections

Patients with allergic rhinitis frequently present exacerbation of the atopic symptoms during viral infections of the upper respiratory tract. Also, allergic rhinitis makes the mucosa more...

A Sedation/Cognition/EEG Study Using AZD6280 and Comparator

The purpose of the study is to determine the effects of AZD6280 compared to lorazepam on sleepiness, concentration and brain activity.

Non-inferiority Clinical Trial of Dexchlorpheniramine (Cream Versus Lotion) in the Relief of Sunburn Related Symptoms

Topical antihistamines can be used to promote relief of sunburn related symptoms (erythema, itch and burning sensations). Dexchlorpheniramine maleate 1% cream is a topical antihistamine fo...

The Impact of Lorazepam on Cognition in APOE e4 Carriers

We expect the results of this pilot study to justify a larger study that follows people to determine if certain tests of memory and attention, performed while sleepiness is induced by a si...

PubMed Articles [1030 Associated PubMed Articles listed on BioPortfolio]

On the issue of the detection of pregabalin and lorazepam in the cases of their joint presence for the purpose of chemical toxicological studies.

Data on the detection of joint presence of pregabalin and lorazepam in the biological objects and material evidence. Aim of this study is to develop a method of the detection of pregabalin and lorazep...

Phenobarbital and symptom-triggered lorazepam versus lorazepam alone for severe alcohol withdrawal in the intensive care unit.

A symptom-triggered lorazepam regimen is the standard for treating alcohol withdrawal syndrome (AWS) in an inpatient setting. However, in severe AWS, lorazepam requirements can reach significant amoun...

Comparison of intranasal midazolam versus intravenous lorazepam for seizure termination and prevention of seizure clusters in the adult epilepsy monitoring unit.

The objective of the study was to compare the performance of intravenous (IV) lorazepam (IVL) and intranasal midazolam (INM) for seizure termination and prevention of seizure clusters in adults admitt...

Profiles and trajectories of impaired social cognition in people with Prader-Willi syndrome.

People with Prader-Willi syndrome (PWS) have a distinctive behavioral phenotype that includes intellectual disability, compulsivity, inattention, inflexibility and insistence on sameness. Inflexibilit...

Thinking in action: Need for Cognition predicts Self-Control together with Action Orientation.

Need for Cognition describes relatively stable interindividual differences in cognitive motivation. Previous research has shown relations of Need for Cognition to Self-Control-a capacity that can be b...

Medical and Biotech [MESH] Definitions

A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Measures of spatial cognition and memory.

Intellectual or mental process whereby an organism becomes aware of or obtains knowledge.

Disturbances in the mental process related to thinking, reasoning, and judgment.

A mechanism of information stimulus and response that may control subsequent behavior, cognition, perception, or performance. (From APA Thesaurus of Psychological Index Terms, 8th ed.)

More From BioPortfolio on "Effects of H1-Antagonist on Cognition"

Quick Search

Relevant Topic

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...


Searches Linking to this Trial