Advertisement

Topics

Intravenous Lidocaine and Postoperative Outcomes After Cardiac Surgery

2014-07-24 14:14:23 | BioPortfolio

Summary

This study is being done to determine if lidocaine, administered during surgery and for 24 hours after surgery can reduce inflammation, thereby reducing the risk of atrial fibrillation and delirium after surgery. Participants undergoing cardiac surgery will be randomized to receive either lidocaine or placebo.

Description

Subjects undergoing cardiac surgery are randomized into one of two groups.

- Group 1: Intravenous Lidocaine Group

- Group 2: Intravenous placebo Group

Either Lidocaine or placebo is administered throughout surgery and 24 hours after surgery.

Patients in both groups will undergo cognitive assessments,quality of life assessments and functional recovery assessments post-surgery.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Conditions

Cardiac Surgery

Intervention

Lidocaine, Lidocaine, Placebo

Location

Cleveland Clinic/Hillcrest
Mayfield Heights
Ohio
United States
44124

Status

Recruiting

Source

Outcomes Research Consortium

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:14:23-0400

Clinical Trials [2319 Associated Clinical Trials listed on BioPortfolio]

Lidocaine For Neuroprotection During Cardiac Surgery

The purpose of this study is to see if a drug called lidocaine prevents cognitive injury (a decline in mental abilities) after heart surgery. Lidocaine is currently FDA approved and is com...

Lidocaine and Ketamine in Abdominal Surgery

This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdo...

Validating a New Non-invasive Approach to Testing Lidocaine Effectiveness

This work will assess the reliability of a simple painless test for the effectiveness of the commonly used local anesthetic lidocaine

Impact of Intravenous Lidocaine During Colorectal Surgery on Pain and Immune Functions

This study evaluates the impact of intraoperative intravenous lidocaine administered during laparoscopic colorectal surgery on the intraoperative remifentanil consumption as well as postop...

Lidocaine and Pain Management in First Trimester Abortions

The purpose of this study is to examine the effect of lidocaine (a numbing medication) inside the uterus on patient pain during an early abortion, compared to the paracervical block (lidoc...

PubMed Articles [14060 Associated PubMed Articles listed on BioPortfolio]

Serum Concentrations of Lidocaine During Bariatric Surgery.

Lidocaine has been shown to be clinically beneficial during bariatric surgery. However, information about lidocaine serum concentrations in this setting is scarce. This prospective clinical trial incl...

Population pharmacokinetic model for tumescent lidocaine in women undergoing breast cancer surgery.

Tumescent lidocaine anesthesia (TLA) is an opportunity to perform mastectomy for breast cancer without general anesthesia in elderly women. Few reports are available on the pharmacokinetics of lidocai...

Intranasal lidocaine for acute management of primary headaches: a systematic review.

Intranasal lidocaine has been studied and recommended as an alternative in the management of acute headache. The objective of this systematic review was to evaluate the efficacy and safety of intranas...

Topical Transdermally Delivered Lidocaine and Benzocaine Compared to Compounded Lidocaine/Tetracaine During Microfocused Ultrasound With Visualization Treatment.

The efficacy of various pre-medication strategies for comfort management during microfocused ultrasound with visualization (MFU-V) treatment has not been studied. The present objective was to compare ...

Quadratus Lumborum Block Versus Perioperative Intravenous Lidocaine for Postoperative Pain Control in Patients Undergoing Laparoscopic Colorectal Surgery: A Prospective, Randomized, Double-blind Controlled Clinical Trial.

To investigate the comparative analgesic efficacy of systemic lidocaine and quadratus lumborum (QL) block in laparoscopic colorectal surgery.

Medical and Biotech [MESH] Definitions

A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.

A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)

A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.

A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

More From BioPortfolio on "Intravenous Lidocaine and Postoperative Outcomes After Cardiac Surgery"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...


Searches Linking to this Trial