Preventing Childhood Antibiotic-Associated Diarrhea by Prebiotics

2014-08-27 03:24:58 | BioPortfolio


Prospective randomized double-blind study on the effect of prebiotics (inulin and fructo-oligosaccharides) in the prevention of antibiotic-associated diarrhea in children.


Group will get either the product or placebo blindly throughout antibiotic treatment with additional 14 days.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention


Antibiotic-Associated Diarrhea


Inulin and fructo-oligosaccharides., Placebo


Soroka Medical Center


Active, not recruiting


Soroka University Medical Center

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:24:58-0400

Clinical Trials [675 Associated Clinical Trials listed on BioPortfolio]

Fructo-Oligosaccharides and Irritable Bowel Syndrome

Fructo-oligosaccharides are known as prebiotic ingredients to modulate the composition of the intestinal microbiota and particularly to stimulate the growth of Bifidobacteria. Imbalance of...

Prebiotic Effect of a Jelly Containing Short Chain Fructo-Oligosaccharides and Sideritis Euboea Extract

The human intestinal microflora is characterized as a complex and dynamic microbial ecosystem with crucial contribution to our nutrition and welfare. Health-promoting genera such as Bifido...

Effects of Arabinoxylan-Oligosaccharides Compared to Other Prebiotics in Healthy Subjects

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Effects of follow-on Formula Enriched on Short-chain Fructooligosaccharides (scFOS) on Immune Response in Healthy Infants

In this study the investigators hypothesized that the chronic intake of fructo-oligosaccharides would increase fecal immunoglobulin A (IgA) specific to poliovirus vaccination and bifidobac...

Effect of Probiotic on Antibiotic-Associated Diarrhea

Diarrhea is a common side effect of antibiotics; it may prolong hospital stay, increase the risk of other infections, develop into more serious forms of disease, and lead to premature disc...

PubMed Articles [2787 Associated PubMed Articles listed on BioPortfolio]

Inulin with different degrees of polymerization modulates composition of intestinal microbiota in mice.

The study aimed to analyse the global influences of dietary inulin with different degrees of polymerization (DP) on intestinal microbial communities. 6-week-old male C57BL/6J mice were treated with fr...

Antibiotic Therapy for Acute Watery Diarrhea and Dysentery.

Diarrheal disease affects a large proportion of military personnel deployed to developing countries, resulting in decreased job performance and operational readiness. Travelers' diarrhea is self-limit...

Effect of Butyrate and Inulin Supplementation on Glycemic Status, Lipid Profile and Glucagon- Like Peptide 1 Level in Patients with Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Trial.

Studies on humans with diabetes mellitus showed that the crosstalk between the intestinal microbiota and the host has a key role in controlling the disease. The aim of this study was to evaluate the e...

Is it worth adding loperamide to antibiotic treatment of traveler’s diarrhea?

Travelers' diarrhea is a frequent condition, especially in those traveling to high-risk areas. Although antibiotic treatment reduces the duration of diarrhea, it has been suggested adding loperamide c...

A Double Blind, Randomized, Placebo-Controlled Trial of Lactobacillus acidophilus for the Treatment of Acute Watery Diarrhea in Vietnamese Children.

Probiotics are the most frequently prescribed treatment for children hospitalized with diarrhea in Vietnam. We were in uncertain of the benefits of probiotics for the treatment of acute watery diarrhe...

Medical and Biotech [MESH] Definitions

Oligosaccharides containing various types of glycosidic linkages that yield branching or antennae. The number of antennae (such as bi-, tri-, tetra-, or penta-antennary) in the oligosaccharides on the PROTEOGLYCANS; GLYCOPROTEINS; or LIPOPOLYSACCHARIDES contribute to their biological activities, such as receptor binding and metabolism.

Infection with any of the rotaviruses. Specific infections include human infantile diarrhea, neonatal calf diarrhea, and epidemic diarrhea of infant mice.

Acute disease of cattle caused by the bovine viral diarrhea viruses (DIARRHEA VIRUSES, BOVINE VIRAL). Often mouth ulcerations are the only sign but fever, diarrhea, drop in milk yield, and loss of appetite are also seen. Severity of clinical disease varies and is strain dependent. Outbreaks are characterized by low morbidity and high mortality.

DIARRHEA occurring in infants from newborn to 24-months old.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

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