Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers

2014-08-27 03:24:58 | BioPortfolio


Some leg ulcers do not seem to respond that well to the standard treatments that we currently use. One reason for this may be that there are high levels of bacteria in the ulcer which may be slowing down the rate of healing. Because we need to be careful about when we use antibiotics, this study will look at another way of killing bacteria in the ulcer. This new method involves putting a special gel on the ulcer and then shining a particular type of light (visible red light) onto the ulcer for a short period of time.

In the first part of the study, a single treatment with the gel and light will be investigated. At the moment we are not sure of how many times it is best to use this treatment, so the second part of the study will compare whether or not using the treatment twice a week for 6 weeks is any better than once a week for 12 weeks.

Across the UK 105 people with chronic leg ulcers will be asked to take part in this study (9 in part 1 and 96 in part 2). Up to 10 sites will be involved including Cardiff University and hospitals in Bradford, Harrogate, Dundee, Truro, Airdrie, Hull, Plymouth and the Wirral.

The research is funded by Photopharmica Ltd.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment


Chronic Leg Ulcers


Topical PPA904 gel and light, Topical placebo gel plus light


Dermatology Department, Monklands Hospital
United Kingdom





Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:24:58-0400

Clinical Trials [3890 Associated Clinical Trials listed on BioPortfolio]

The Effect of Topical Sunscreen Plus Antioxidant Against the Visible Light Biological Effects

Visible light is known to induce pigmentation in darker skin types. The investigators aim to study the effects of visible light on the skin after topical application of sunscreen plus anti...

Efficacy Evaluation of Products Against Long Wavelength Ultraviolet A1 and Visible Light Induced Biological Effects

The purpose of this study is to evaluate the efficacy of topical products in providing protection against the visible light and ultraviolet A1 (UVA1) part of sunlight. Ultraviolet radiatio...

The Comparative Efficacy of an Over the Counter Light Therapy Mask vs Over the Counter Topical Benzoyl Peroxide 2.5% and Used in Combination With Over the Counter Adapalene Gel 0.1% for Mild to Moderate Acne

This is a single-center prospective study of two standard-of-care treatments to evaluate the efficacy of the Neutrogena® Light Therapy Acne Mask an Over the Counter (OTC) Blue/Red light L...

Study to Compare Different Light Therapies (Narrowband Ultraviolet B vs PUVA) for Hand and Foot Skin Diseases.

Hand and foot skin diseases, such as dermatitis and psoriasis, that do not respond to topical creams can be treated with ultraviolet light therapy. Topical psoralen plus ultraviolet A (PU...

Topical 5-ALA-PDT With Blu-U Therapy Versus Topical 5-ALA With Pulse Dye Laser In Treating Recalcitrant Acne Vulgaris

The goal of this study is to compare how efficient two different types of PDTs are when used in combination with topical 5-ALA. The two types of PDT lights are Blu-U light and Candela V-b...

PubMed Articles [12976 Associated PubMed Articles listed on BioPortfolio]

Synergistic Effects of the 308-nm Excimer Light and Topical Calcipotriol for the Treatment of Chronic Hand Eczema: A Randomized Controlled Study.

Though topical corticosteroid is a standard treatment for chronic hand eczema (CHE), it can cause many adverse effects. Topical calcipotriol and monochromatic 308-nm excimer light (MEL) are new altern...

The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review.

Clinicians have increasingly adopted the widespread use of topical agents to manage chronic wound infections, despite limited data on their effectiveness in vivo. This study sought to evaluate the evi...

Topical 5% Minoxidil versus Topical 0.2% Glyceryl Trinitrate in Treatment of Chronic Anal Fissure: A Randomized Clinical Trial.

Chronic anal fissure (CAF) is a common painful anal condition. Medical treatment of CAF involves the use of agents that induce chemical sphincterotomy. The present trial aimed to compare the efficacy ...

Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomised, double-blind, vehicle-controlled Phase 2a study.

Management of chronic hand eczema (CHE) remains a challenge; effective topical treatment is still limited to corticosteroids.

Minocycline 1.5% Foam for the Topical Treatment of Moderate-to-Severe Papulopustular Rosacea: Results of Two Phase 3, Randomized, Clinical Trials.

Efficacious topical medications for rosacea are needed. FMX103 1.5% is a novel, topical minocycline foam that may have therapeutic benefits in treating rosacea, while minimizing systemic side effects ...

Medical and Biotech [MESH] Definitions

Therapy using oral or topical photosensitizing agents with subsequent exposure to light.

Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.

Treatment using irradiation with light of low power intensity so that the effects are a response to the light and not due to heat. A variety of light sources, especially low-power lasers are used.

The adjustment of the eye to variations in the intensity of light. Light adaptation is the adjustment of the eye when the light threshold is increased; DARK ADAPTATION when the light is greatly reduced. (From Cline et al., Dictionary of Visual Science, 4th ed)

An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.

More From BioPortfolio on "Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers"

Quick Search

Searches Linking to this Trial