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Does Sildenafil Increase Exercise Performance in Air Pollution?

2014-07-24 14:14:58 | BioPortfolio

Summary

The purpose of this study is to examine if the ingestion of a standard dose of sildenafil enhances the athletic performance of competitive athletes when exercising in a high pollutant environment verses a low air pollutant environment.

Description

This study will evaluate effects of sildenafil on exercise performance while breathing high levels of emission exhaust ultrafine and fine particulate matter. Exercise performance will be measured by work accumulation (total kJ) during a 6-min maximal effort cycle ergometer ride (CER) done immediately after 30 min cycling at 75% of 6 min mean watts determined from familiarization trial. Peak oxygen consumption, cardiac output, pulmonary artery pressure, diffusion capacity(DLco), and SaO2 will be determined for each trial. Blood and urine will be analyzed for sildenafil using LC/MS.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Basic Science

Conditions

Pulmonary Hypertension

Intervention

sildenafil, placebo

Location

Marywood University
Scranton
Pennsylvania
United States
18509

Status

Completed

Source

Marywood University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:14:58-0400

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