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Treatment of Bronchial Asthma With Borage and Echium Seed Oils

2014-08-27 03:25:43 | BioPortfolio

Summary

The aim of this trial is to determine the efficacy of a combination of two botanicals oils, borage seed oil and echium seed oil, as a potential treatment for bronchial asthma.

Description

Leukotrienes are important in the pathogenesis of inflammation, and leukotriene modifying drugs are now an established treatment for bronchial asthma and rhinitis. Drugs that inhibit the biosynthesis of leukotrienes are likely to be more effective than the currently available drugs that antagonize a single leukotriene receptor. Dietary supplementation with gamma linolenic acid (GLA) in borage seed oil provides effective inhibition of leukotriene generation but also increases circulating free arachidonic acid (AA), which has pro-inflammatory potential. The n-3 fatty acid, eicosapentaenoic acid (EPA), prevented the conversion of GLA to AA. However, EPA is extracted from fish oil, is not well-tolerated due to its taste, and at higher doses appeared to blunt the inhibition of leukotriene biosynthesis by GLA. Stearidonic acid (SDA) is a precursor of EPA that is extracted from Echium plantagineum; it is converted to EPA in humans and it does not have the organoleptic properties of EPA.

We recently completed a dose-ranging study in which we determined the dose of SDA that is sufficient to inhibit the rise in circulating levels of arachidonic acid while maintaining effective inhibition of leukotriene generation.

The goal of the present study is to test the efficacy of dietary supplementation with GLA and SDA (provided in borage seed oil and echium seed oil) in treating bronchial asthma.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Bronchial Asthma

Intervention

Borage Seed Oil and Echium Seed Oil, Corn Oil

Location

Asthma Research Center, Brigham and Women's Hospital
Boston
Massachusetts
United States
02115

Status

Recruiting

Source

Brigham and Women's Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:25:43-0400

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Medical and Biotech [MESH] Definitions

A group of alcohol-soluble seed storage proteins from the endosperm of corn.

A plant species of the family POACEAE. It is a tall grass grown for its seed, corn, used as food and animal fodder.

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A subset of various vascular plants (also known as the Tracheophyta) which include seed-bearing and non seed-bearing species.

The state of failure to complete the process of GERMINATION of an intact viable seed, due to intrinsic physical, molecular, genetic, or physiological parameters under otherwise favourable prevailing conditions.

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