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Study Evaluating Long-Term Safety of MOA-728 in Subjects With Opioid-Induced Constipation

2014-07-24 14:15:02 | BioPortfolio

Summary

This is a one-year study to evaluate the long-term safety and tolerability of the subcutaneous (just under the skin) injection form of MOA-728 for the treatment of opioid-induced constipation in subjects with nonmalignant pain. The study consists of a 2 week screening period, a 48 week open-label treatment period and a 2 week follow-up period. Subjects will need to agree to self-administer subcutaneous injections, complete daily diaries, and check-in via a daily telephone call during that year-long period.

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Constipation

Intervention

N-methylnaltrexone bromide (MOA-728)

Location

Birmingham
Alabama
United States
32542

Status

Active, not recruiting

Source

Wyeth

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:15:02-0400

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Medical and Biotech [MESH] Definitions

Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.

A synthetic polymer which agglutinates red blood cells. It is used as a heparin antagonist.

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A scopolamine derivative and CHOLINERGIC ANTAGONIST that functions as a BRONCHODILATOR AGENT. It is used in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

A diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)

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