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PURPOSE: This randomized clinical trial is studying contrast-enhanced MRI in women with ductal breast carcinoma in situ and in healthy volunteers.
- To compare ductal carcinoma in situ (DCIS)-optimized MRI with standard clinical MRI, in terms of conspicuity of DCIS lesion, agreement of disease extent with biopsy, and overall image quality (i.e., artifact level, uniformity of fat suppression, contrast to noise ratio and signal to noise ratio), in women with DCIS of the breast.
- To compare two DCIS-optimized MRIs for variability in enhancement levels for DCIS.
- To examine the effect of the menstrual cycle on the variability of background enhancement levels in healthy volunteers.
OUTLINE: This is a multicenter study. Patients are randomized to 1 of 2 arms.
- Arm I: Patients undergo standard clinical contrast-enhanced MRI over approximately 30-45 minutes. No more than 3 days later, patients undergo ductal carcinoma in situ (DCIS)-optimized contrast-enhanced MRI.
- Arm II: Patients undergo DCIS-optimized contrast-enhanced MRI over approximately 30-45 minutes. No more than 3 days later, patients undergo a second DCIS-optimized contrast-enhanced MRI.
Healthy volunteers undergo DCIS-optimized contrast-enhanced MRI as in arm II.
Allocation: Randomized, Masking: Single Blind, Primary Purpose: Diagnostic
contrast-enhanced magnetic resonance imaging
UCSF Helen Diller Family Comprehensive Cancer Center
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:25:49-0400
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