Advertisement

Topics

Effects of Rosuvastatin on Aortic Stenosis Progression

2014-08-27 03:25:55 | BioPortfolio

Summary

The purpose of this study is to assess the effects of rosuvastatin compared to usual care in patients diagnosed with aortic valvular stenosis. Patients must have a diagnosis of mild to moderate aortic stenosis (AS) and no clinical indication for the use of cholesterol lowering agents. A multi-centre, randomized, double-blind, placebo-controlled study, with a two year recruitment period, and a treatment duration of a minimum of 3 years from the time of the last patient randomized to a maximum of 5 years.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Aortic Stenosis

Intervention

Rosuvastatin, Placebo

Location

Research site
Calgary
Alberta
Canada

Status

Completed

Source

AstraZeneca

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:25:55-0400

Clinical Trials [971 Associated Clinical Trials listed on BioPortfolio]

Statin Therapy in Asymptomatic Aortic Stenosis

There is evidence that the degenerative changes leading to aortic stenosis are caused by a chronic inflammatory process. Furthermore the development of aortic stenosis is partially depende...

The Potential of Candesartan to Retard the Progression of Aortic Stenosis

The present study defines a blinded, randomized, placebo-controlled, prospective study, the aim of which is to determine the influence of effective treatment with Type 1 angiotensin II (An...

Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis

Aortic stenosis is a major cause of morbidity around the world. Progressive aortic stenosis leads to cardiac hypertrophy as a compensatory response. A maladaptive response may lead to hear...

18F-NaF Uptake and Aortic Stenosis Progression

This study aims to evaluate whether baseline 18F-sodium fluoride uptake activity at aortic valve could predict aortic stenosis progression in moderate aortic stenosis. Patients with moder...

Early Detection of Aortic Stenosis in the Community During Flu Vaccination

Prospective cohort study to test the hypothesis that patients identified with severe aortic stenosis are under-diagnosed and under-treated. Such patients shall be identified by auscultatio...

PubMed Articles [2469 Associated PubMed Articles listed on BioPortfolio]

Diminutive Porcelain Ascending Aorta with Supravalvular Aortic Stenosis.

This case report describes a case of a 49-year-old male, with a past medical history significant for congenital aortic stenosis, who presented with progressive shortness of breath and decreased stamin...

Two-step strategy for the treatment of complex coronary artery disease and aortic stenosis in a patient with severely impaired left ventricular function.

Coronary artery disease and aortic stenosis frequently coexist. The pathophysiology of both conditions is similar where atherosclerosis is the hallmark feature. Risk factors for aortic stenosis are al...

Transcatheter aortic valve replacement in women.

This review examines the treatment options for women with severe aortic stenosis. It is known that female sex is associated with poorer outcomes after surgical aortic valve replacement. With the intro...

Pathological significance of lipoprotein(a) in aortic valve stenosis.

Aortic valve stenosis (AVS) affects a significant percentage of our elderly population and younger subjects with familial hypercholesterolemia. Lipoprotein(a) [Lp(a)] has been associated with AVS in r...

In-hospital outcomes comparison of transfemoral vs transapical transcatheter aortic valve replacement in propensity-matched cohorts with severe aortic stenosis.

Transcatheter aortic valve replacement (TAVR) is the preferred option for high-risk patients with severe aortic stenosis. The preferred access for TAVR is transfemoral (TF). Alternatives include the t...

Medical and Biotech [MESH] Definitions

A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

A pathological constriction occurring in the region below the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

A pathological constriction occurring in the region above the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

Surgical treatment for severe AORTIC VALVE STENOSIS. Transcatheter aortic valve replacement (TAVR) is used as an alternative option in patients who are deemed at high risk or inoperable for traditional open-heart surgery.

A type of constriction that is caused by the presence of a fibrous ring (discrete type) below the AORTIC VALVE, anywhere between the aortic valve and the MITRAL VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

More From BioPortfolio on "Effects of Rosuvastatin on Aortic Stenosis Progression"

Advertisement
Quick Search
Advertisement
Advertisement

 

Searches Linking to this Trial