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The purpose of this study is to determine if a novel, unique, non-contact optical imaging device(camera) developed at the Beckman Laser Institute (BLI), called Modulated Imaging (MI), can help us customize Photodynamic therapy (PDT) treatment for patients with skin cancer. The device developed will be used to measure tissue optical properties that effect the PDT treatment process (e.g. spectral absorption and scattering coefficients, oxy- and deoxy-hemoglobin, water, melanin) and use that information to provide customized laser light treatment.
The current standard of care for skin cancer is excision, curettage and electrodesiccation and/or cryosurgery. These methods result in scarring, whereas PDT, on the other hand, offers the potential for enhanced treatment with less scarring. In spite of this advantage that PDT has over current techniques, it has still not achieved the consistent performance required to gain clinical acceptance.
The researchers want to use an imaging system that can characterize the tissue and photosensitizer optical properties and use that information to drive a treatment light projection system that can spatially optimize the light irradiance for personalized treatment, thus improving outcomes.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Supportive Care
Modulated Imaging (MI)
Beckman Laser Institute Medical clinic
Enrolling by invitation
University of California, Irvine
Published on BioPortfolio: 2014-08-27T03:26:32-0400
The purpose of this study is to obtain skin spectroscopic data from two imaging systems. Comparison groups: - Skin Spect dermoscope - Spatially modulated quantitative spectr...
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The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.
CONFORMAL RADIOTHERAPY that combines several intensity-modulated beams to provide improved dose homogeneity and highly conformal dose distributions.
Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.
Tumors or cancer of the SKIN.
The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.
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Head and neck cancers
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Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells. In vertebrates, it is composed of blo...