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The purpose of this research is to provide a better understanding of how exercise (walking) affects non-alcoholic fatty liver disease (NAFLD) in overweight people. NAFLD, which is common in obese people, occurs when the liver has too much fat.
Non-alcoholic fatty liver disease (NAFLD) affects about 20% of adults in the United States. The prevalence of NAFLD is four to five times higher in obese than lean persons and is associated with insulin resistance and the metabolic syndrome. Decreasing calorie intake and increasing physical activity has been recommended as primary therapy for NAFLD, but the independent effect of aerobic exercise is unknown. The current exercise guidelines for disease prevention and weight management range from 150 min/wk, recommended by the Centers for Disease Control and the American College of Sports Medicine, to 300 min/wk, recommended by the Institute of Medicine. However, it is not known whether aerobic exercise alone can improve NAFLD, and which recommended dose of exercise might have the most beneficial effects. The purpose of this proposal is to determine the effect of two levels of aerobic exercise on: 1) hepatic fat content; 2) hepatic lipoprotein kinetics; 3) insulin sensitivity; 4) plasma inflammatory markers; and 5) potential cellular mechanism that regulate insulin action and inflammation. We hypothesize that aerobic exercise will decrease hepatic fat content, improve hepatic, skeletal muscle, and adipose tissue insulin sensitivity, and decrease inflammation in a dose-dependent fashion. The results from this study will help determine exercise guidelines for obese patients with NAFLD, and lay the groundwork for future studies evaluating the effects of exercise on metabolic diseases associated with obesity.
This proposal involves conducting a randomized controlled trial that will randomize obese subjects with NAFLD (> 5% hepatic fat content) to one of three groups: Group 1 (Control, no exercise), Group 2 (Low-Dose Aerobic Exercise- 150 min/wk of supervised exercise performed at 45-55% of O2 max), and Group 3 (Moderate-Dose Aerobic Exercise - 300min/wk of supervised exercise performed at 45-55% of O2 max) to determine the effects of low and moderate doses of aerobic exercise.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Non-alcoholic Fatty Liver Disease (NAFLD)
low dose exercise, high dose exercise
Washington University School of Medicine
Washington University School of Medicine
Published on BioPortfolio: 2014-07-23T21:19:55-0400
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The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
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