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Bone Marrow Derived Adult Stem Cells for Acute Anterior Myocardial Infarction

2014-07-23 21:20:07 | BioPortfolio

Summary

Study hypothesis :

The purpose of this study is to determine whether Intracoronary infusion of autologous bone marrow derived progenitor cells to patients undergoing primary angioplasty for acute anterior myocardial infarction will lead to an improvement in cardiac function greater than that seen by placebo alone.

Aims

- To demonstrate that intracoronary delivery of autologous bone marrow progenitor cells is safe.

- To demonstrate that it is feasible to deliver autologous bone marrow derived stem cells within hours of the primary angioplasty procedure

- To demonstrate the effects of autologous bone marrow derived stem cells on cardiac function using tissue Doppler echocardiography, cardiac MRI and left ventriculography.

- To show a difference in cardiac function between patients treated with cells and saline(placebo).

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Acute AMI

Intervention

Bone marrow derived progenitor cells or placebo infusion, Placebo infusion

Location

London Chest Hospital, Barts and The London NHS Trust
Bethnal Green
London
United Kingdom
E2 9JX

Status

Recruiting

Source

Barts & The London NHS Trust

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:20:07-0400

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Medical and Biotech [MESH] Definitions

Cells derived from BONE MARROW that circulate in the adult bloodstream and possess the potential to proliferate and differentiate into mature ENDOTHELIAL CELLS.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.

Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.

Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.

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