Advertisement

Topics

Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy

2014-08-27 03:27:34 | BioPortfolio

Summary

The purpose of this research is to determine if a subject's own bone marrow tissue can help regenerate bone in the area of his/her jaw where a tooth has been removed using Tissue Repair Cell (TRC) Therapy.

Description

A sample of the subject's bone marrow tissue will be collected and sent to a laboratory where it will be processed to form cells. The new cells are transplanted into the tooth socket after the tooth has been removed. The researchers are testing to see if these cells (TRC) will help form bone. The research will also determine if the implant the subject receives will be more stable in the area with new bone growth.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Alveolar Bone Defects

Intervention

Tissue Repair Cell therapy, Tissue Repair Cells (TRC)

Location

University of Michigan Center for Oral Health Research
Ann Arbor
Michigan
United States
48106

Status

Active, not recruiting

Source

University of Michigan

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:27:34-0400

Clinical Trials [8600 Associated Clinical Trials listed on BioPortfolio]

Mesenchymal Stem Cell Augmentation in Patients Undergoing Arthroscopic Rotator Cuff Repair

The primary objective of this study is to compare the clinical outcomes of arthroscopic rotator cuff repair with and without augmentation of mesenchymal stem cells (MSCs). Mesenchymal stem...

Long-Term Outcome of Pediatric Traumatic Wound Repair: Suture Versus Tissue Adhesive

This project is an observational trial investigating wound cosmetic appearance after repair of traumatic skin lacerations in the head area of pediatric patients with two different approach...

Stromal Vascular Fraction Cell Therapy to Improve the Repair of Rotator Cuff Tears

Rotator cuff disease is one of the most prevalent musculoskeletal conditions across the world. Patients with chronic rotator cuff tears often have substantial muscle atrophy and fatty infi...

Randomized, Multi-center Phase II Clinical Trial for the Regeneration of Cartilage Lesions in the Knee

The purpose of this study is to investigate the efficacy of an engineered cartilage transplant (N-TEC) in comparison to a cell-activated matrix (N-CAM) for the treatment of articular carti...

Tissue Repair in Stem Cell Transplant Recipients

Primary Objective: 1. To determine whether rhG-CSF treatment will increase the frequency of donor-derived cells contributing to repair of damaged epithelial/endothelial or solid organ-spe...

PubMed Articles [39964 Associated PubMed Articles listed on BioPortfolio]

Inhaled TRIM72 Protein Protects Ventilation Injury to the Lung through Injury-guided Cell Repair.

[Rationale] Studies showed that TRIM72 is essential for repair of alveolar cell membrane disruptions, and exogenous TRIM72 protein (rhT72) demonstrated tissue-mending properties in animal models of ti...

Emerging Roles of Extracellular Vesicles in Cardiac Repair and Rejuvenation.

Cell therapy has received significant attention as a therapeutic approach to restore cardiac function after myocardial infarction. Accumulating evidence supports that beneficial effects observed with ...

Potentiating Renal Regeneration using Mesenchymal Stem Cells.

The potential of a Mesenchymal Stem Cell (MSC) therapy to accelerate the repair of ischemically damaged human kidneys during 24 hours of warm perfusion was evaluated. The hypothesis was that by admini...

ScarCon ETRS 2018 Joint Meeting Scar Academy and the European Tissue Repair Society: Okura Hotel, Amsterdam, The Netherlands, May 31-June 2, 2018.

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair.

Lightweight (LW) polypropylene (PP) meshes better adapt to host tissue, causing less fibrosis and inflammatory responses than high-density meshes. Mesh fixation using tissue adhesives (TA) that replac...

Medical and Biotech [MESH] Definitions

Historically, tissue transplantation, especially of refrigerated tissue (after Filatov). It was theorized that nonspecific substances, capable of initiating restorative processes, formed in tissues when refrigerated. Cell therapy (after Niehans) refers to implantation of tissue by injection. Originally this involved fresh cells but later frozen or lyophilized cells.

Historically, tissue transplantation, especially of refrigerated tissue (after Filatov). It was theorized that nonspecific substances, capable of initiating restorative processes, formed in tissues when refrigerated. Cell therapy (after Niehans) refers to implantation of tissue by injection. Originally this involved fresh cells but later frozen or lyophilized cells.

Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.

The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.

Techniques for enhancing and directing cell growth to repopulate specific parts of the PERIODONTIUM that have been damaged by PERIODONTAL DISEASES; TOOTH DISEASES; or TRAUMA, or to correct TOOTH ABNORMALITIES. Repopulation and repair is achieved by guiding the progenitor cells to reproduce in the desired location by blocking contact with surrounding tissue by use of membranes composed of synthetic or natural material that may include growth inducing factors as well.

More From BioPortfolio on "Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Osteoporosis
Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...


Searches Linking to this Trial