Dopamine in Orthostatic Tolerance

2014-08-27 03:27:53 | BioPortfolio


One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate. We will also study whether increasing dietary salt improves symptoms during upright posture. Finally, we will examine whether the dietary sodium level influences serum DBH activity and whether DBH level influences the response to sodium. DBH levels and the function of the sympathetic or involuntary nervous system will be assessed in normal volunteers and in patients with postural tachycardia syndrome (POTS).

Study Design

Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Supportive Care


Postural Tachycardia Syndrome


dietary sodium, dietary sodium, dietary sodium


Vanderbilt University
United States


Active, not recruiting


Vanderbilt University

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:27:53-0400

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