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The aim of the present PPS3 study is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.
Overall, 10 000 men and women will be recruited during two years for an extensive clinical examination including a 2h holter ECG, a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Thereafter, the cardiovascular morbidity and mortality of the participants will be followed up for 10 years at least.
Observational Model: Cohort, Time Perspective: Prospective
Spider flash EKG, echocardiography tracking, step test
Investigations Pré cliniques et Preventives de Paris
Institut National de la Santé Et de la Recherche Médicale, France
Published on BioPortfolio: 2014-08-27T03:28:07-0400
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A venomous New World spider with an hourglass-shaped red mark on the abdomen.
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Cardiovascular disease (CVD)
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