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Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm

2014-08-27 03:29:16 | BioPortfolio

Summary

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Asthma, Exercise Induced

Intervention

Hyperpnea challenge

Location

Vermont Lung Center
Colchester
Vermont
United States
05446

Status

Completed

Source

University of Vermont

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:29:16-0400

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Medical and Biotech [MESH] Definitions

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

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