Track topics on Twitter Track topics that are important to you
RATIONALE: Radiolabeled monoclonal antibodies can find tumor cells and carry tumor-killing substances to them without harming normal cells. Drugs used in chemotherapy, such as gemcitabine and floxuridine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiolabeled monoclonal antibody therapy together with gemcitabine and floxuridine after surgery may kill any tumor cells that remain after surgery.
PURPOSE: This phase I trial is studying the side effects and best dose of floxuridine when given as a hepatic arterial infusion together with radiolabeled monoclonal antibody therapy and gemcitabine in treating patients with metastatic colorectal cancer and liver metastases.
- To determine the maximum tolerated dose and dose-limiting toxicity of hepatic arterial infusion of floxuridine when administered in combination with gemcitabine hydrochloride and yttrium Y 90 anti-CEA monoclonal antibody cT84.66 in patients with metastatic colorectal carcinoma and liver metastases.
- To study the feasibility and toxicities of this regimen.
- To evaluate the biodistribution, clearance, and metabolism of yttrium Y 90 anti-CEA monoclonal antibody cT84.66 and indium In 111 anti-CEA monoclonal antibody cT84.66.
- To estimate radiation doses to whole body, normal organs, and tumor through serial nuclear imaging.
- To correlate pre- and post-therapy proteomic profiles with toxicities and antitumor effects.
OUTLINE: This is a dose-escalation study of floxuridine.
Patients receive floxuridine as a continuous hepatic arterial infusion on days 1-14. Patients also receive a dosimetry dose of indium In 111 anti-CEA monoclonal antibody cT84.66 IV followed by a therapeutic dose of yttrium Y 90 anti-CEA monoclonal antibody cT84.66 IV on day 9 and gemcitabine hydrochloride IV over 30 minutes on days 9 and 11. Treatment repeats every 6-10 weeks for up to 3 courses* in the absence of disease progression or unacceptable toxicity. Patients may receive additional systemic therapy at the discretion of the treating physician.
NOTE: *Patients may receive up to 4 courses of floxuridine as a continuous hepatic arterial infusion.
Blood and urine samples are collected periodically for proteomic analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; pharmacokinetic analysis; and analysis of antibody activity and metabolism by radiometric high performance liquid chromatography.
Primary Purpose: Treatment
floxuridine, gemcitabine hydrochloride, proteomic profiling, high performance liquid chromatography, matrix-assisted laser desorption/ionization time of flight mass spectrometry, pharmacological study, adjuvant therapy, yttrium Y 90 anti-CEA monoclonal an
City of Hope Comprehensive Cancer Center
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:31:49-0400
RATIONALE: Diagnostic procedures, such as proteomic profiling, may help predict whether ovarian cancer will come back. PURPOSE: This clinical trial is studying how well proteomic profilin...
The primary objective is to examine the impact on progression-free survival of targeted therapy for breast cancer suggested by proteomic and genomic profiling.
RATIONALE: Studying samples of tumor tissue, blood, and urine in the laboratory from patients receiving erlotinib may help doctors predict how patients will respond to treatment. PU...
RATIONALE: Finding specific proteins in the blood may help doctors tell whether a patient has ovarian cancer. PURPOSE: This clinical trial is studying how well proteomic profiling works i...
RATIONALE: Evaluating specific proteins in the blood may be an effective and noninvasive procedure to help doctors determine if a patient has early non-small cell lung cancer. PURPOSE: Th...
In this manuscript we aimed at the simultaneous separation and quantification of Gemcitabine and Irinotecan hydrochloride (injected both as single components and in combination) from Sprague Dawley ra...
Compatibility of Baclofen, Carvedilol, Hydrochlorothiazide, Mercaptopurine, Methadone Hydrochloride, Oseltamivir Phosphate, Phenobarbital, Propranolol Hydrochloride, Pyrazinamide, Sotalol Hydrochloride, Spironolactone, Tacrolimus Monohydrate, Ursodeoxycholic Acid, and Vancomycin Hydrochloride Oral Suspensions Compounded with SyrSpend SF pH4.
Compounded liquid medication is frequently required in children to allow easy dose adjustment and overcome swallowing difficulties. The objective of this study was to evaluate the stability of oral su...
We report a type of dissolving microneedles (DMNs) which was made of composite matrix materials of hydroxypropyl methyl cellulose (HPMC) and poly(methylvinylether‑co‑maleic anhydride) (PMVE/MA cop...
Lipid polymer hybrid nanoparticles (LPHNs) combine the characteristics and beneficial properties of both polymeric nanoparticles and liposomes. The objective of this study was to design and optimize g...
The adverse impacts of AFB on gut-microbiota dependent metabolism in F344 rats were assessed via ultra-high performance liquid chromatography (UHPLC)-profiling and UHPLC-mass spectrometry (MS) metabol...
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
The removal of a soluble component from a liquid mixture by contact with a second liquid, immiscible with the carrier liquid, in which the component is preferentially soluble. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Miniaturized methods of liquid-liquid extraction.
A pharmaceutical preparation of sitagliptin phosphate and metformin hydrochloride that is used in the treatment of TYPE 2 DIABETES.
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...
Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...