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The Role of Cerebral Hemodynamics in Moyamoya Disease

2014-08-27 03:32:25 | BioPortfolio

Summary

The purpose of this study is to determine if people with moyamoya disease who have insufficient blood flow are at a higher risk for stroke.

Description

Moyamoya disease is a rare medical disorder that affects the blood vessels (pipes that transport blood) in the brain. In Moyamoya disease, the large blood vessels in the middle of the brain close down over time. The cause of this disorder is unknown. In order to compensate for this narrowing, the body grows new small blood vessels around the blockage. These small branches grow larger (and may be more numerous) to give the disorder its name. "Moyamoya" is the Japanese term for "puff of smoke" and is used to describe the hazy appearance of these small blood vessels on an angiogram.

Treatment for moyamoya is difficult because so little is known about the disease. Some people never have a stroke while others may have several. It is likely that the strokes are due to insufficient blood flow to the brain. There are surgical procedures that may improve blood flow to the brain, however, these procedures may cause complications and may not always improve the blood flow.

The main purpose of this study is to determine if people with moyamoya disease who have insufficient blood flow are at a higher risk for stroke. In this study researchers will learn more about the risks and potential benefits of surgical treatment. This information will help decide if there are people at higher risk for stroke who might benefit from surgery or if there are those at a lower risk who might not benefit.

In this study, participants will undergo baseline clinical and laboratory evaluation. Measurements of blood flow to the brain and oxygen use will be obtained using by positron emission tomography (PET). Participants will be followed for up to 5 years. PET studies will be conducted one and three years after enrollment to determine if blood flow improves over time. Participants treated with surgery (at the discretion of their treating physicians) will also be followed for perioperative complications, improvement in blood flow, and long term risk of stroke.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Moyamoya

Location

Washington University School Of Medicine, 510 South Kingshighway Blvd
St. Louis
Missouri
United States
63110

Status

Recruiting

Source

Washington University School of Medicine

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:32:25-0400

Clinical Trials [15 Associated Clinical Trials listed on BioPortfolio]

The Effect of RIC on TIA/Stroke in Children With Moyamoya Disease

Moyamoya disease is a common reason of transient ischemic attack (TIA) and stroke in children. Remote ischemic conditioning (RIC) has been shown to prevent recurrent stroke in intracranial...

Relationship Between Endothelial Progenitor Cells and Revascularization Effect of Moyamoya Disease

Moyamoya disease is a chronic cerebrovascular disease,The typical pathological manifestations are the stenosis or occlusion of the distal internal carotid artery and/or middle cerebral a...

Effect of Surgical Revascularization on Hemorrhagic Moyamoya Disease

Moyamoya Disease(MMD), also known as spontaneous basilar artery occlusion, is characterized by the gradual thickening of arterial intima at the distal carotid artery and the proximal porti...

Effects of Remote Ischemic Pre-Conditioning in Moyamoya Disease Patients

In the present study, investigators evaluated whether RIPC reduce the major neurological complications in adult moyamoya disease patients undergoing encephaloduroarteriosynangiosis (EDAS).

Efficacy and Safety of rTMS for Cognitive Rehabilitation in Moyamoya Disease

The purpose of this study is to evaluate the safety and effectiveness of transcranial magnetic stimulation (TMS) therapy in moyamoya patients who received surgical revascularization.

PubMed Articles [46 Associated PubMed Articles listed on BioPortfolio]

Moyamoya-related stroke risk during pregnancy: an evidence-based reappraisal.

Moyamoya is a rare, yet classic etiology of stroke in young adults, predominantly affecting women of childbearing age. However, the impact of pregnancy on the natural history of symptomatic moyamoya r...

Development of bilateral dural arteriovenous fistulae following pial synangiosis for moyamoya syndrome: case report.

Moyamoya syndrome predisposes patients to ischemic or hemorrhagic stroke due to progressive narrowing of intracranial vessels with subsequent small-vessel collateralization. Dural arteriovenous fistul...

Case-Control Study of Cephalometrics in Moyamoya Patients.

To determine whether cranial metrics consistently differed between moyamoya patients and age-, sex-, and race-matched controls.

Surgical outcomes for pediatric moyamoya: a systematic review and meta-analysis.

The optimal revascularization for pediatric moyamoya for reducing the incidence of future stroke events remains to be determined.

Misdiagnoses and delay of diagnoses in Moyamoya angiopathy-a large Caucasian case series.

The lacking awareness of healthcare providers bears the risk of delayed or false diagnoses in rare diseases. No systematic data about misdiagnoses of Moyamoya angiopathy (MMA) are available.

Medical and Biotech [MESH] Definitions

A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults.

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