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PURPOSE: This randomized phase I trial is studying the side effects and best way to give topical myristyl nicotinate cream on the skin of healthy volunteers.
- To determine if topical myristyl nicotinate (MN) is a safe, tolerable treatment in healthy volunteers.
- To determine if topically administered MN cream is associated with any significant local or systemic toxicity in normal human subjects in a one-month period.
OUTLINE: Participants are randomized to 1 of 2 treatment arms and serve as their own controls.
- Arm I: Participants apply topical myristyl nicotinate to one forearm and topical placebo to the other forearm once daily for 4 weeks.
- Arm II: Participants receive treatment as in arm I but on opposite forearms. All participants undergo blood collection for chemistry analysis (SMA-20 and CBC) at baseline and at 2 and 4 weeks.
Allocation: Randomized, Control: Placebo Control, Masking: Double-Blind, Primary Purpose: Prevention
Healthy, no Evidence of Disease
topical myristyl nicotinate cream, placebo
Arizona Cancer Center at University of Arizona Health Sciences Center
University of Arizona
Published on BioPortfolio: 2014-08-27T03:32:50-0400
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A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.
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An enzyme that catalyzes the hydrolysis of nicotinamide to nicotinate and ammonia. EC 188.8.131.52.
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