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Topical Myristyl Nicotinate Cream on the Skin of Healthy Volunteers

2014-08-27 03:32:50 | BioPortfolio

Summary

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of topical myristyl nicotinate cream may stop skin cancer from forming.

PURPOSE: This randomized phase I trial is studying the side effects and best way to give topical myristyl nicotinate cream on the skin of healthy volunteers.

Description

OBJECTIVES:

- To determine if topical myristyl nicotinate (MN) is a safe, tolerable treatment in healthy volunteers.

- To determine if topically administered MN cream is associated with any significant local or systemic toxicity in normal human subjects in a one-month period.

OUTLINE: Participants are randomized to 1 of 2 treatment arms and serve as their own controls.

- Arm I: Participants apply topical myristyl nicotinate to one forearm and topical placebo to the other forearm once daily for 4 weeks.

- Arm II: Participants receive treatment as in arm I but on opposite forearms. All participants undergo blood collection for chemistry analysis (SMA-20 and CBC) at baseline and at 2 and 4 weeks.

Study Design

Allocation: Randomized, Control: Placebo Control, Masking: Double-Blind, Primary Purpose: Prevention

Conditions

Healthy, no Evidence of Disease

Intervention

topical myristyl nicotinate cream, placebo

Location

Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson
Arizona
United States
85724-5024

Status

Completed

Source

University of Arizona

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:32:50-0400

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