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A Phase 1 Study of ARQ 197 in Adult Patients With Advanced Solid Tumors

2014-08-27 03:33:03 | BioPortfolio

Summary

This is an open label, single arm, dose escalation study of ARQ 197 in patients with advanced solid tumors.

Description

Patients will take ARQ 197 orally twice daily continuously at dose levels specified for their respective dose cohorts. The ARQ 197 starting dose will be a total daily dose of 200 mg (100 mg bid). ARQ 197 treatment will be continued until progression of disease, unacceptable toxicity, or another discontinuation criterion is met. In the case of toxicity, dose adjustment is permitted. A treatment cycle is designed as four weeks (28 days) and will be repeated without therapy interruption.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Cancer, Advanced Solid Tumors

Intervention

ARQ 197

Location

The Royal Marsden Hospital
Sutton
Surrey
United Kingdom
SM25PT

Status

Completed

Source

ArQule

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:33:03-0400

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