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Azithromycin as a Quorum-Sensing Inhibitor for the Prevention of Pseudomonas Aeruginosa Ventilator-Associated Pneumonia

2014-08-27 03:33:08 | BioPortfolio

Summary

The purpose of this study is to assess the clinical efficacy of azithromycin, used as a quorum-sensing blocker, when compared to placebo for preventing or delaying the occurrence of pneumonia in ventilated patients colonized with Pseudomonas aeruginosa.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Conditions

Pneumonia, Ventilator-Associated

Intervention

azithromycin, placebo

Location

Intensive Care Unit, Clinique Saint-Pierre
Ottignies
Louvain
Belgium
1340

Status

Terminated

Source

Anbics Management-Services Ag

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:33:08-0400

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Medical and Biotech [MESH] Definitions

Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by cross bacterial infections in hospitals (NOSOCOMIAL INFECTIONS).

Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.

Pneumonia caused by infection with bacteria of the family RICKETTSIACEAE.

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A species of the genus PNEUMOVIRUS causing pneumonia in mice.

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