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Chemotherapy and Avastin Followed by Maintenance Treatment With Avastin +/- Tarceva

2014-08-27 03:33:35 | BioPortfolio

Summary

Chemotherapy and bevacizumab is given for 4 months. Patients who have not progressed will continue with maintenance treatment with either bevacizumab (Avastin) alone, or bevacizumab and erlotinib (Tarceva).

Description

Patients with metastatic colorectal cancer will be treated with standard chemotherapy according to the investigators choice. In addition to chemotherapy, Avastin (bevacizumab) will be given during the treatment period. After the chemotherapy is finished (after 18 weeks), maintenance therapy will be given and the patients will be randomized to treatment with either with Avastin alone or Avastin in combination with Tarceva (erlotinib). Patients with progressive disease, or patients suitable to curative resection of metastases will be taken out of study.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Metastatic Colorectal Cancer

Intervention

erlotinib (Tarceva), bevacizumab (Avastin)

Location

Vejle Hospital, Department of Oncology
Copenhagen
Denmark
22185

Status

Active, not recruiting

Source

Lund University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:33:35-0400

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