IMRT Tomotherapy for Esophagus Cancer

2014-07-24 14:19:14 | BioPortfolio


The hypothesis of this study is that the use of IMRT instead of conventional 4-field irradiation in patients with locally-advanced esophagus cancer receiving adjuvant RT is a feasible treatment alternative. IMRT may reduce the rate of pulmonary, cardiac, and bowel toxicity while allowing an intensified dose of radiation therapy to be delivered to the cancer.


In this study, we will give you radiation therapy through a system called tomotherapy. Tomotherapy is designed to target the tumor and regions at risk more precisely than conventional radiation therapy. Tomotherapy involves delivering the radiation doses in a corkscrew or helical fashion, attacking the tumor from 360 degrees, rather than from only 3 or 4 directions.

Study Design

Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Esophagus Cancer




Washington University School of Medicine
St. Louis
United States




Washington University School of Medicine

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T14:19:14-0400

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Medical and Biotech [MESH] Definitions

Tumors or cancer of the ESOPHAGUS.

A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).

Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.

A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.

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