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A Study of the Proper Dosage of Lovastatin and Docetaxel for Patients With Cancer

2014-08-27 03:34:07 | BioPortfolio

Summary

This purpose of this study is to evaluate the use of two medications, docetaxel and lovastatin. There are two phases. Subjects in Phase I can have any cancer. This phase will determine the highest dose of lovastatin and docetaxel that can be given safely as well as the safety of combining the two drugs and the effect on the subject's tumor. Phase II will administer lovastatin and docetaxel only to subjects who have breast cancer tumors.

Description

The primary objective of this study is to determine the maximum tolerated dose (MTD) of lovastatin and docetaxel in patients with various different cancers (phase I). Once the MTD for this drug combination has been determined, patients with breast cancer will be entered into a single cohort, the phase II portion of this study, and treated with the MTD doses of both lovastatin and docetaxel.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Any Cancer

Intervention

Lovastatin and Docetaxel

Location

Holden Comprehensive Cancer Center
Iowa City
Iowa
United States
52242

Status

Terminated

Source

University of Iowa

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:34:07-0400

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