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A Pilot Study of Daptomycin for Antimicrobial Prophylaxis

2014-07-24 14:19:38 | BioPortfolio

Summary

The goals of the study are to evaluate the feasibility of using daptomycin as a prophylactic antimicrobial agent in patients undergoing cardiac surgery, to determine the rates of surgical site infection, and to evaluate the occurrence of adverse events.

Study Design

Allocation: Non-Randomized, Control: Historical Control, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Staphylococcal Infections

Intervention

daptomycin 6 mg/kg IV

Location

Duke University Medical Center
Durham
North Carolina
United States
27710

Status

Terminated

Source

Duke University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:19:38-0400

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PubMed Articles [3406 Associated PubMed Articles listed on BioPortfolio]

Comparative evaluation of VITEK® 2 and three commercial gradient strip assays for daptomycin susceptibility testing of Staphylococcus aureus.

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DAPTOMYCIN TREATMENT IN VASCULAR GRAFT GRAM-POSITIVE INFECTIONS.

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Medical and Biotech [MESH] Definitions

Infections with bacteria of the genus STAPHYLOCOCCUS.

Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.

A diffuse, non-pitting induration of the skin of unknown etiology that occurs most commonly in association with diabetes mellitus, predominantly in females. It typically begins on the face or head and spreads to other areas of the body, sometimes involving noncutaneous tissues. Often it is preceded by any of various infections, notably staphylococcal infections. The condition resolves spontaneously, usually within two years of onset. (From Dorland, 27th ed)

An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Poisoning by staphylococcal toxins present in contaminated food.

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