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Study of the Efficacy and Safety of Intravenous vs Oral Acetaminophen for Treatment of Fever in Healthy Adult Males

2014-08-27 03:34:52 | BioPortfolio

Summary

To assess the rapidity of onset of antipyretic effect and the efficacy and safety of a single dose of IV APAP versus PO acetaminophen in the treatment of fever induced by a standard dose of endotoxin

Description

To assess the rapidity of onset of antipyretic effect and the efficacy and safety of a single dose of IV APAP versus PO acetaminophen in the treatment of fever induced by a standard dose of endotoxin

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Fever

Intervention

IV APAP, Oral acetaminophen

Location

New Orleans Center for Clinical Research-Knoxville
Knoxville
Tennessee
United States
37920

Status

Completed

Source

Cadence Pharmaceuticals

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:34:52-0400

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Medical and Biotech [MESH] Definitions

Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)

A branch of dentistry dealing with diseases of the oral and paraoral structures and the oral management of systemic diseases. (Hall, What is Oral Medicine, Anyway? Clinical Update: National Naval Dental Center, March 1991, p7-8)

An intermittent fever characterized by intervals of chills, fever, and splenomegaly each of which may last as long as 40 hours. It is caused by BARTONELLA QUINTANA and transmitted by the human louse.

The practice of personal hygiene of the mouth. It includes the maintenance of oral cleanliness, tissue tone, and general preservation of oral health.

Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.

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