Studying Thyroid Cancer and Other Thyroid Diseases in Participants Who Were Children in Ukraine During the Chernobyl Nuclear Power Plant Accident

2014-07-24 14:19:51 | BioPortfolio


RATIONALE: Measuring changes in the thyroid gland after radiation exposure may help doctors learn about the long-term effects of radiation exposure and help the study of thyroid cancer and other thyroid diseases.

PURPOSE: This clinical trial is studying thyroid cancer and other thyroid diseases in participants who were children in Ukraine during the Chernobyl nuclear power plant accident.



- Carry out valid and credible assessments of the early and late morphologic and functional changes in the thyroid glands of individuals exposed to radiation from radioactive materials released as a result of the Chernobyl nuclear power plant accident in 1986.

- Examine other possible risk factors, including dietary iodine intake during and after 1986 and the ingestion of potassium iodide for thyroid protection shortly after the accident.

OUTLINE: Participants complete a questionnaire about residence (at the time of the Chernobyl nuclear power plant accident), health, diet, lifestyle, and family history of thyroid disease. Participants also undergo diagnostic thyroid examinations, including palpation, ultrasound scanning, and thyroid hormone and other laboratory testing. Fine-needle aspirations are performed, if indicated. Some participants may also undergo urine sample collection to determine urinary iodine content. Participants are reexamined every 2 years for at least 6 years for thyroid cancer morbidity and mortality.

If the participant was under 10 years of age at the time of the nuclear power plant accident (or if the mother was pregnant with the participant at the time of the accident), the questionnaire is completed by the participant's parents.

Study Design



Head and Neck Cancer


laboratory biomarker analysis, questionnaire administration, examination, fine-needle aspiration, study of high risk factors, ultrasound imaging


Research Centre for Radiation Medicine




National Cancer Institute (NCI)

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T14:19:51-0400

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